Structural Balance of Resting-state Brain Network in Attention Deficit Hyperactivity Disorder.

IF 1.1 Q4 NEUROSCIENCES

Basic and Clinical Neuroscience Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI:10.32598/bcn.2024.276.3

Ruzbeh Fakhari, Alireza Moradi, Reza Ebrahimpour, Reza Khosrowabadi

{"title":"Structural Balance of Resting-state Brain Network in Attention Deficit Hyperactivity Disorder.","authors":"Ruzbeh Fakhari, Alireza Moradi, Reza Ebrahimpour, Reza Khosrowabadi","doi":"10.32598/bcn.2024.276.3","DOIUrl":null,"url":null,"abstract":"Introduction: The study of brain functional networks in attention deficit hyperactivity disorder (ADHD) has provided useful information about the hyper- or hypo-connectivity between distinct brain regions. Nevertheless, the impact of negative links (antisynchrony) and their topology on the stability of the network still must be investigated.Methods: In this study, we hypothesized that the effect of dysconnectivity and antisynchrony should mainly be local and may not influence the overall stability and flexibility of the network in ADHD. Therefore, differences in brain functional organization of ADHD individuals were compared to a typically developed group using the structural balance theory.Results: Our results did not show any significant differences in the balance-energy of the resting-state network between healthy individuals and three subtypes of ADHD. However, a negative correlation was found between behavioral measures of ADHD and balance energy, highlighting that the higher disorder index may push the network to a less flexible (more balanced) state.Conclusion: We hope these findings enhance our understanding of the systemic mechanism behind ADHD.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"299-308"},"PeriodicalIF":1.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265431/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic and Clinical Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/bcn.2024.276.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/18 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: The study of brain functional networks in attention deficit hyperactivity disorder (ADHD) has provided useful information about the hyper- or hypo-connectivity between distinct brain regions. Nevertheless, the impact of negative links (antisynchrony) and their topology on the stability of the network still must be investigated.

Methods: In this study, we hypothesized that the effect of dysconnectivity and antisynchrony should mainly be local and may not influence the overall stability and flexibility of the network in ADHD. Therefore, differences in brain functional organization of ADHD individuals were compared to a typically developed group using the structural balance theory.

Results: Our results did not show any significant differences in the balance-energy of the resting-state network between healthy individuals and three subtypes of ADHD. However, a negative correlation was found between behavioral measures of ADHD and balance energy, highlighting that the higher disorder index may push the network to a less flexible (more balanced) state.

Conclusion: We hope these findings enhance our understanding of the systemic mechanism behind ADHD.

查看原文本刊更多论文

注意缺陷多动障碍静息状态脑网络的结构平衡。

导读：对注意缺陷多动障碍（ADHD）的脑功能网络的研究为不同脑区之间的高或低连接提供了有用的信息。然而，负链路（反同步）及其拓扑结构对网络稳定性的影响仍需进一步研究。方法：在本研究中，我们假设连接障碍和反同步性的影响主要是局部的，可能不会影响ADHD网络的整体稳定性和灵活性。因此，使用结构平衡理论将ADHD个体的脑功能组织差异与正常发育组进行比较。结果：我们的研究结果没有显示健康个体和三种亚型ADHD之间静息状态网络的平衡能量有任何显著差异。然而，ADHD的行为测量与平衡能量之间存在负相关，这表明较高的障碍指数可能会将网络推向更不灵活（更平衡）的状态。结论：我们希望这些发现能加深我们对ADHD背后的系统机制的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.