Sara A Jablonski, Danielle M Marturello, Karen L Perry, Romy M Heilmann, Joerg M Steiner, Daniel K Langlois
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引用次数: 0
Abstract
Objective: To investigate changes in gastrointestinal biomarkers over time in dogs undergoing elective orthopedic surgery and in dogs with acute nonspecific diarrhea (AD).
Methods: Prospective cohort study of 20 dogs undergoing surgical repair of cranial cruciate ligament disease (CCL cohort) and 8 dogs with AD. Serum concentrations of cobalamin, folate, methylmalonic acid, and C-reactive protein and fecal calprotectin concentrations were measured before and 12 to 18 hours, 4 weeks, and 8 weeks after surgery in the CCL group. These biomarkers were also measured in AD dogs at initial evaluation and 4 and 8 weeks postrecovery.
Results: Serum cobalamin (437 ± 186 ng/L) and folate concentrations (10.5 ± 4.8 ng/mL) at 12 to 18 hours were lower than corresponding cobalamin (630 ± 235 ng/L; P < .001) and folate concentrations (14.61 ± 6.3 ng/mL; P = .001) before surgery in CCL dogs. However, serum cobalamin (637 ± 195 ng/L) and folate concentrations (13.8 ± 5.7 ng/mL) at 4 weeks were higher than at 12 to 18 hours (P < .001 and P = .01, respectively) and similar to baseline. All 3 AD dogs with serum cobalamin concentrations below the reference interval at baseline had serum cobalamin concentrations within the reference interval at 4 weeks.
Conclusions: Major orthopedic surgery and acute nonspecific enteropathy transiently lowered serum cobalamin and folate concentrations in dogs.
Clinical relevance: Serum folate and cobalamin should be interpreted cautiously in the immediate postoperative setting or during acute gastrointestinal illness. Abnormalities should be reevaluated at a later date before pursuing other diagnostics or instituting supplementation.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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