Pharmacokinetics of subcutaneous bupivacaine liposome injectable suspension indicate an extended absorption and elimination profile in swan geese (Anser cygnoid).
Yasmeen Prud'homme, Kate Gustavsen, Heather Knych, Kathryn Gamble
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引用次数: 0
Abstract
Objective: To determine the pharmacokinetics of a single dose of bupivacaine liposome injectable suspension (BLIS) after SC administration to swan geese (Anser cygnoid). The goal was to assess its potential as an extended-release local anesthetic infiltration in avian patients. It was hypothesized that BLIS at this dose would have low maximal plasma concentrations and a prolonged elimination profile similar to published mammalian data and without adverse effects.
Methods: A single dose of BLIS at 5.3 mg/kg was infiltrated SC in 6 adult swan geese (3 males and 3 females). Over the following 96 hours, blood samples were collected at 9 time points for analysis of plasma concentrations of bupivacaine. Concentrations were determined using HPLC-MS and plotted against time for pharmacokinetic analysis via nonlinear modeling.
Results: The harmonic mean terminal half-life was 14.8 ± 5.5 hours. The mean maximum concentration was 74 ± 21.9 ng/mL and was achieved in all geese within 8 hours. No adverse effects were noted.
Conclusions: These results indicate that BLIS in swan geese has an extended absorption and elimination profile compared to local anesthetics in current use in avian species.
Clinical relevance: Protracted duration of local anesthesia in birds may improve patient care, welfare, and surgical outcomes by allowing a reduction of systemic anesthetic and analgesic doses and reducing the frequency of restraint or isolation needed for treatment.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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