A Yellow Color Emitting Turn-On Detect and Degrade Molecular Optode for Sarin Analog Applicable for Detoxification of Fruits and Vegetables

IF 3 4区 化学 Q2 CHEMISTRY, ANALYTICAL
Luminescence Pub Date : 2025-07-19 DOI:10.1002/bio.70258
Shubham Lama, Sabbir Ahamed, Najmin Tohora, Jyoti Chourasia, Ayan Kumar Mahanty, Shraddha Rai, Upika Darnal, Subekchha Pradhan, Sudhir Kumar Das
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Abstract

Nerve agents seriously threaten the viability of the contemporary environment and public health. In the current contribution, we have introduced a Schiff base-based probe, MIDA to “detect and degrade” sarin simulant, diethyl chlorophosphate (DCP) in solution and gaseous phases. MIDA is highly selective and sensitive towards DCP emitting a highly intensified yellow fluorescence having detection and quantification limits within the μM range. It was shown that DCP could be identified in a combination of similar hazardous analytes using a convenient strained paper strip-based assay. DCP vapor was identified via a dip-stick and dip vial conical flask experiment, which could be a useful photonic tool for selective detection of sarin in real threat scenarios. To validate DCP detection even in a variety of soil types, including sand, field, and clay, we also demonstrated soil sample analysis using diverse DCP-spiked soils. A smartphone-based detection method has also been demonstrated to detect and quantify DCP and may be helpful for on-spot sarin detection. Additionally, when Zn2+ ions are introduced, the MIDA-DCP pair degrades into nontoxic forms. MIDA is a highly sensitive, selective, and “detect and degrade” probe for the detection and degradation of DCP, a toxic nerve agent sarin's simulant in hazardous circumstances.

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一种适用于果蔬解毒的沙林类似物黄色发光开启检测降解分子光电器件
神经毒剂严重威胁着当代环境和公众健康的生存能力。在目前的贡献中,我们介绍了一种基于希夫碱的探针,MIDA来“检测和降解”沙林模拟物,氯磷酸二乙酯(DCP)在溶液和气相。MIDA对发射高度强化黄色荧光的DCP具有高度选择性和敏感性,检测和定量限在μM范围内。结果表明,DCP可以在类似危险分析物的组合中识别,使用方便的张力纸条为基础的分析。通过蘸棒和蘸瓶锥形烧瓶实验鉴定了DCP蒸汽,为沙林在实际威胁环境下的选择性检测提供了一种有用的光子工具。为了验证DCP在各种土壤类型(包括沙子、田野和粘土)中的检测效果,我们还演示了使用不同的DCP添加土壤进行土壤样品分析。基于智能手机的检测方法也已被证明可以检测和量化DCP,并可能有助于现场沙林检测。此外,当引入Zn2+离子时,MIDA-DCP对降解为无毒形式。MIDA是一种高度敏感,选择性和“检测和降解”探针,用于检测和降解DCP,一种在危险环境下的有毒神经毒剂沙林的模拟物。
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来源期刊
Luminescence
Luminescence 生物-生化与分子生物学
CiteScore
5.10
自引率
13.80%
发文量
248
审稿时长
3.5 months
期刊介绍: Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.
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