Recent trends in ionic-liquids mediated synthesis of azepine, diazepine and triazepine

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-07-15 DOI:10.1016/j.tetlet.2025.155749

Shivangi Jaiswal , Anshita Paliwal , Jaya Dwivedi , Swapnil Sharma

{"title":"Recent trends in ionic-liquids mediated synthesis of azepine, diazepine and triazepine","authors":"Shivangi Jaiswal , Anshita Paliwal , Jaya Dwivedi , Swapnil Sharma","doi":"10.1016/j.tetlet.2025.155749","DOIUrl":null,"url":null,"abstract":"<div><div>The synthesis of seven-membered heterocycles received significant interest due to a broad range of applications such as materials science, pharmaceuticals, and agrochemicals. For moving in a sustainable approach in organic synthesis, ionic liquids play a potential role in making the process greener and atom economy. Ionic liquids are powerful in catalyzing the reaction, offering unique advantages such as high thermal stability, tunable physicochemical properties, and the ability to act as solvents and catalysts. Ionic liquids have the ability to enhance reaction rates, improve selectivity, and reduce environmental impact compared to conventional organic synthesis. Moreover, ionic liquids stabilize the reaction intermediates, and selectivity transforms the reactant into complex products. This review highlights ionic liquids' role in synthesizing seven-membered heterocycles such as azepines, diazepines, and triazepines. The rationale of the review is to highlight a high-yielding green synthetic methodology for desired organic transformation for varied applications.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"169 ","pages":"Article 155749"},"PeriodicalIF":1.5000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403925002989","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

Abstract

The synthesis of seven-membered heterocycles received significant interest due to a broad range of applications such as materials science, pharmaceuticals, and agrochemicals. For moving in a sustainable approach in organic synthesis, ionic liquids play a potential role in making the process greener and atom economy. Ionic liquids are powerful in catalyzing the reaction, offering unique advantages such as high thermal stability, tunable physicochemical properties, and the ability to act as solvents and catalysts. Ionic liquids have the ability to enhance reaction rates, improve selectivity, and reduce environmental impact compared to conventional organic synthesis. Moreover, ionic liquids stabilize the reaction intermediates, and selectivity transforms the reactant into complex products. This review highlights ionic liquids' role in synthesizing seven-membered heterocycles such as azepines, diazepines, and triazepines. The rationale of the review is to highlight a high-yielding green synthetic methodology for desired organic transformation for varied applications.

Abstract Image

查看原文本刊更多论文

离子液体介导合成氮卓类、二氮卓类和三氮卓类药物的最新进展

七元杂环化合物的合成由于在材料科学、制药和农用化学品等方面的广泛应用而引起了人们的极大兴趣。为了在有机合成中采用可持续的方法，离子液体在使过程更环保和原子经济方面发挥着潜在的作用。离子液体在催化反应方面具有强大的作用，具有高热稳定性、可调的物理化学性质以及作为溶剂和催化剂的能力等独特优势。与传统的有机合成相比，离子液体具有提高反应速率、提高选择性和减少环境影响的能力。此外，离子液体稳定了反应中间体，选择性地将反应物转化为复杂的产物。本文综述了离子液体在七元杂环化合物如氮卓类、二氮卓类和三氮卓类化合物合成中的作用。回顾的基本原理是强调一种高产的绿色合成方法，用于各种应用所需的有机转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.