Lithium: Emerging frontiers in metallopharmaceutical therapeutics

IF 3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular immunology Pub Date : 2025-07-17 DOI:10.1016/j.molimm.2025.07.001

Shuai Tong, Jingxuan Xiao, Xin Zhang, Jingwei Ma

引用次数: 0

Abstract

The successful application of lithium salts in treating bipolar disorder marks a milestone in metallotherapeutics. Ongoing research has revitalized the clinical application of this "classic drug" lithium carbonate. Since the late 19th century, lithium salts have been found effective in improving bipolar disorder and established as a standard treatment. Recent studies highlight lithium's potential in neuroprotection, metabolic regulation, and cancer therapy due to its unique physicochemical properties. Its clinical applications continue to expand, demonstrating significant value in fields such as metalloimmunotherapy. This review summarizes the mechanisms of lithium and its growing role in treating diverse diseases.

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锂：金属药物治疗的新兴前沿

锂盐治疗双相情感障碍的成功应用标志着金属治疗学的一个里程碑。正在进行的研究重振了这种“经典药物”碳酸锂的临床应用。自19世纪末以来，锂盐被发现对改善双相情感障碍有效，并被确立为一种标准治疗方法。由于其独特的物理化学性质，最近的研究强调了锂在神经保护、代谢调节和癌症治疗方面的潜力。其临床应用不断扩大，在金属免疫治疗等领域显示出重要的价值。本文就锂的作用机制及其在治疗多种疾病中的作用进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular immunology 医学-免疫学

CiteScore

6.90

自引率

2.80%

发文量

324

审稿时长

50 days

期刊介绍： Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to: Infection, autoimmunity, transplantation, immunodeficiencies, inflammation and tumor immunology Mechanisms of induction, regulation and termination of innate and adaptive immunity Intercellular communication, cooperation and regulation Intracellular mechanisms of immunity (endocytosis, protein trafficking, pathogen recognition, antigen presentation, etc) Mechanisms of action of the cells and molecules of the immune system Structural analysis Development of the immune system Comparative immunology and evolution of the immune system "Omics" studies and bioinformatics Vaccines, biotechnology and therapeutic manipulation of the immune system (therapeutic antibodies, cytokines, cellular therapies, etc) Technical developments.