The role of sleep traits in prostate, endometrial, and epithelial ovarian cancers: An observational and Mendelian randomisation study

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-07-17 DOI:10.1016/j.canep.2025.102877

Christos V. Chalitsios , Eirini Pagkalidou , Christos K. Papagiannopoulos , Georgios Markozannes , Emmanouil Bouras , Eleanor L. Watts , The Practical Consortium , Rebecca C. Richmond , Konstantinos K. Tsilidis

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引用次数: 0

Abstract

Background

Sleep traits may influence cancer risk; however, their associations with prostate (PCa), endometrial (ECa), and epithelial ovarian (EOCa) cancer remain unclear.

Methods

We conducted an observational analysis using the UK Biobank cohort and a two-sample Mendelian randomisation (MR) analysis to investigate the association between six sleep traits-duration, chronotype, insomnia, daytime napping, daytime sleepiness, and snoring-with PCa, ECa, and EOCa risk. Cox proportional hazards models were used for the observational analysis, while the inverse variance-weighted (IVW) method was applied in MR, with multiple sensitivity analyses. A Bonferroni correction was applied to account for multiple testing.

Results

Among 8608 PCa, 1079 ECa, and 680 EOCa incident diagnoses (median follow-up: 6.9 years), snoring was associated with reduced EOCa risk (HR=0.78, 95 %CI: 0.62–0.98), while daytime sleepiness was associated with increased EOCa risk (HR=1.23, 95 %CI: 1.03–1.47). However, these associations were not confirmed in MR. MR suggested higher odds of PCa (OR_IVW=1.05, 95 %CI: 1.01–1.11) and aggressive PCa (OR_IVW=1.10, 95 %CI: 1.02–1.19) for evening compared to morning chronotype. None of the findings survived multiple testing correction.

Conclusion

Sleep traits were not associated with PCa, ECa, or EOCa risk; however, an evening chronotype may increase PCa risk. Further research is needed to verify this association and investigate potential underlying mechanisms.

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睡眠特征在前列腺癌、子宫内膜癌和上皮性卵巢癌中的作用：一项观察性孟德尔随机研究

睡眠特征可能影响癌症风险；然而，它们与前列腺癌（PCa）、子宫内膜癌（ECa）和卵巢上皮癌（EOCa）的关系尚不清楚。方法采用英国生物银行队列和双样本孟德尔随机化（MR）分析进行观察性分析，研究持续时间、睡眠类型、失眠、白天午睡、白天嗜睡和打鼾等六种睡眠特征与PCa、ECa和EOCa风险之间的关系。观察分析采用Cox比例风险模型，MR分析采用逆方差加权（IVW）法，进行多敏感性分析。采用Bonferroni校正来解释多重检验。结果在8608例PCa、1079例ECa和680例EOCa事件诊断（中位随访时间：6.9年）中，打鼾与EOCa风险降低相关（HR=0.78, 95 %CI: 0.62-0.98），而白天嗜睡与EOCa风险增加相关（HR=1.23, 95 %CI: 1.03-1.47）。然而，这些关联并没有在MR中得到证实。MR表明，与早晨的时间型相比，晚上的PCa （ORIVW=1.05, 95 %CI: 1.01-1.11）和侵袭性PCa （ORIVW=1.10, 95 %CI: 1.02-1.19）的几率更高。这些发现都没有经过多次测试修正。结论：睡眠特征与PCa、ECa或EOCa风险无关；然而，晚上的睡眠类型可能会增加前列腺癌的风险。需要进一步的研究来验证这种关联并调查潜在的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.