Mechanisms and benefits of phytochemicals as an alternative therapeutic strategy in female cancers

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2025-07-01 DOI:10.1016/j.chmed.2025.04.002

Yufan Zhao , Shimenghui Deng , Danli Cao , Caiji Lin , Mengzhi Xu , Jiaxing Wang , Lingjie Luo , Shulin Liu , Huidi Liu

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Abstract

Cancer is a highly deadly disease, with breast cancer, cervical cancer, endometrial cancer, and ovarian cancer being the most prevalent in women. However, traditional cancer treatments present challenges due to their strong toxic side effects and adverse reactions. Numerous studies have demonstrated that natural products derived from various plants possess therapeutic and preventive properties against cancer. These phytochemicals have been extensively investigated as a potential alternative to conventional chemotherapy drugs, owing to their safety and efficacy. This article provides a comprehensive review of the recent advances in the chemoprevention and mechanisms of phytochemicals against the four major female cancers. The focus will be on how these phytochemicals regulate cancer cell proliferation, apoptosis, invasion, and metastasis to impede cancer progression. Given their extensive clinical applications, phytochemicals hold great promise in the field of cancer treatment. It hopes that this review will inspire more researchers to explore the potential of these natural compounds in combating female cancers.

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植物化学物质作为女性癌症替代治疗策略的机制和益处

癌症是一种高度致命的疾病，乳腺癌、宫颈癌、子宫内膜癌和卵巢癌是女性中最常见的疾病。然而，传统的癌症治疗方法由于其强烈的毒副作用和不良反应而面临挑战。许多研究表明，从各种植物中提取的天然产物具有治疗和预防癌症的特性。由于其安全性和有效性，这些植物化学物质已被广泛研究作为传统化疗药物的潜在替代品。本文就植物化学物质对女性四种主要癌症的化学预防及其作用机制的研究进展作一综述。重点将是这些植物化学物质如何调节癌细胞的增殖、凋亡、侵袭和转移，以阻止癌症的进展。鉴于其广泛的临床应用，植物化学物质在癌症治疗领域具有很大的前景。希望这篇综述能激励更多的研究人员探索这些天然化合物在对抗女性癌症方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks

期刊介绍： Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.