Case report: A young woman with acute peri‑myocarditis and acute myeloid leukaemia with myelodysplasia-related changes

IF 0.9 Q4 HEMATOLOGY

Leukemia Research Reports Pub Date : 2025-01-01 DOI:10.1016/j.lrr.2025.100527

Zsolt Szakács , Tamás Habon , László Kereskai , László Gopcsa , Hussain Alizadeh

引用次数: 0

Abstract

Background

Clinical presentation in acute myeloid leukaemia (AML) can result in a wide variety of clinical phenotypes.

Case Report

We report the case of a 34-year-old woman who presented with severe peri‑myocarditis and concomitant AML. The patient was treated with 5-azacitidine and venetoclax followed by haploidentical allogenic haematopoetic stem cell transplantation. Unfortunately, the patient developed febrile neutropenia and died because of overwhelming neutropenic sepsis. On autopsy, no evidence of AML was identified neither in bone marrow nor in cardiac tissue.

Conclusion

With this case report, we would like to emphasize the possibility of cardiac involvement in AML as well as the potential application of novel therapeutic agents in AML patients unfit for intensive chemotherapy.

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病例报告：一名年轻女性急性心肌炎和急性髓性白血病伴骨髓增生异常相关改变

背景：急性髓性白血病（AML）的临床表现可导致多种临床表型。病例报告我们报告一例34岁的女性，她表现为严重的心肌炎和伴发急性髓性白血病。患者接受5-阿扎胞苷和venetoclax治疗，随后进行单倍体同种异体造血干细胞移植。不幸的是，患者出现发热性中性粒细胞减少症，并因压倒性的中性粒细胞减少败血症而死亡。在尸检中，骨髓和心脏组织中都没有发现AML的证据。结论通过本病例报告，我们想强调AML累及心脏的可能性，以及新药物在不适合强化化疗的AML患者中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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