Malignant transformation of ameloblastoma: A case report and literature review

Abstract

Ameloblastic carcinoma is an odontogenic malignancy that is divided into a primary type called de novo cancer and a secondary type, a malignant transformation of an existing benign ameloblastoma. Most reported cases of ameloblastic carcinoma occur de novo, while few are caused by malignant degeneration of benign ameloblastoma. This study reports a case of mandibular secondary type ameloblastic carcinoma with malignant transformation 2 months after primary surgery. The patient received extended resection and postoperative radiotherapy. Eight months after operation, the skin flap had good color and soft texture, and the mandibular movement function and facial shape recovered well. We also reviewed 32 cases of secondary type ameloblastic carcinoma and analyzed the clinical features, treatment and results, suggesting that clinicians should pay attention to the possibility of malignant transformation of ameloblastoma and provide guidance for its treatment.