Efficacy of nano-emulsion quercetin gel post third molar extraction

Abstract

AIM

Wound healing encompasses a multifaceted sequence of events, comprising inflammation, blood coagulation, fibroplasia, and collagen deposition. However, following third molar surgeries, patients frequently contend with pain, inflammation, and swelling, presenting significant obstacles to the natural progression of wound healing. Quercetin, a natural flavanol renowned for its myriad health benefits, exhibits potent anti-inflammatory, anti-cancer, anti-viral, and antioxidant properties. Leveraging these attributes, we propose the development and assessment of a Nano Emulsion Quercetin gel for wound healing post 3rd molar surgery. The envisioned Nano Emulsion Quercetin gel holds promise as an innovative, targeted intervention to improve postoperative recovery and outcomes.

Material and methods

The trial cohort was prospectively allocated for treatment of surgical removal of mandibular third molar throughout a 12-month period. Participants were randomly assigned to either with nano-emulsion gel or without nano-emulsion gel groups. Nano-emulsion Quercetin gel was formulated and placed in the socket after 3rd molar removal. Post-operative Edema, pain and soft tissue healing was assessed on day 1, day 3 and day 7. Bone assessment was carried out post operative 1st week, 4th week, and 8th week to observe the bone re-fill in the socket.

Result

The study included total 36 patients (18 Female and 18 male). Group with Nano-Emulsion quercetin gel had a statistically significant influence on reducing post-operative pain and edema. Wound healing with bone formation with Nano-emulsion quercetin gel was significantly better.

Conclusion

This study provides valuable insights into the efficacy of nano-emulsion quercetin gel in reducing post-operative pain, swelling, and promoting superior wound healing following third molar surgery.