Synthesis, characterization and biological investigations of novel phenylthiosemicarbazones

IF 3.2 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Shivani B. Malap, Raju M. Patil
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引用次数: 0

Abstract

In this study the synthesis of novel Phenylthiosemicarbazones were obtained via condensation reaction of 4-Phenylthiosemicarbazide and p–substituted Isonitrosoacetophenones. The structural elucidation have been carried on the basis of Elemental analysis, UV–Visible, 1H NMR, 13C NMR, FTIR and Mass spectral studies. The antimicrobial inhibitory action of the present compounds assessed against selected bacterial and fungal strains. Additionally, the Brine Shrimp Lethality Test (BSLT) has been used to screen these compounds for cytotoxic activity by determining the LC50 value. The obtained LC50 value of compounds L1-L6 was found to be < 1000 ppm. The synthesized compounds exhibit toxicity towards Artemia Salina Leach larvae and are believed to possess anticancer properties, Compound L5 demonstrated the highest level of toxicity, with an LC50 value of 51.65 mg/L. Anticancer screening was determined against triple negative human breast cancer cell line MDA-MB-231. In vitro cytotoxicity of the compounds was evaluated relative to paclitaxel using an MTT assay.

Abstract Image

新型苯硫代氨基脲类化合物的合成、表征及生物学研究
以4-苯基硫代氨基脲和对取代异硝基苯乙酮为原料,通过缩合反应合成了新型苯硫代氨基脲类化合物。通过元素分析、紫外-可见、1H NMR、13C NMR、FTIR和质谱研究对其结构进行了解析。本发明化合物对选定的细菌和真菌菌株的抑菌作用进行了评估。此外,卤虾致死试验(BSLT)已被用于筛选这些化合物的细胞毒性活性,通过确定LC50值。所得化合物l1 ~ l6的LC50值为<;1000 ppm。合成的化合物对Salina Leach幼虫具有一定的毒性,具有一定的抗癌作用,其中化合物L5的LC50值最高,为51.65 mg/L。对三阴性人乳腺癌细胞株MDA-MB-231进行了抗癌筛选。在体外细胞毒性评价的化合物相对于紫杉醇使用MTT试验。
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来源期刊
CiteScore
3.50
自引率
7.70%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.
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