Construction and applications of exosome-microneedle integrated systems

IF 5.2 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics: X Pub Date : 2025-07-15 DOI:10.1016/j.ijpx.2025.100360

Lijie Zheng , Jiting Sun , Lusheng Wang , Zhixian Ding , Yu Tang , Mike Dai , Heng Tang

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引用次数: 0

Abstract

With the rapid advancement of drug delivery technologies, microneedles (MNs) have emerged as a novel transdermal delivery platform due to their ease of administration, minimally invasive nature, and high efficiency. MNs have demonstrated broad applicability for delivering diverse therapeutic agents, including small molecules, nucleic acids, peptides, and proteins. Exosomes (Exos), a class of extracellular vesicles with unique biological functions and significant clinical potential, have attracted increasing attention in recent years. However, their widespread application is limited by issues such as poor stability, low delivery efficiency, and potential safety and immune risks. The integration of Exos with MNs (Exos-MNs) systems offers a promising strategy to address these challenges. This review provides a comprehensive overview of recent advances in Exos-MNs delivery systems, including the technological advances of MNs, biological characteristics and engineering strategy of Exos, and the construction strategies of Exos-MNs. Additionally, we highlight recent developments in the application of Exos-MNs systems and discuss future perspectives and challenges for their clinical translation.

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外泌体-微针集成系统的构建与应用

随着药物给药技术的快速发展，微针（MNs）因其易于给药、微创和高效的特点而成为一种新型的透皮给药平台。MNs已被证明广泛适用于递送各种治疗剂，包括小分子、核酸、多肽和蛋白质。外泌体（Exos）是一类具有独特生物学功能和重要临床潜力的细胞外囊泡，近年来受到越来越多的关注。然而，它们的广泛应用受到稳定性差、递送效率低以及潜在的安全性和免疫风险等问题的限制。Exos与MNs （Exos-MNs）系统的集成为解决这些挑战提供了一种很有前景的策略。本文综述了Exos-MNs传递系统的最新进展，包括MNs的技术进展、Exos的生物学特性和工程策略以及Exos-MNs的构建策略。此外，我们强调了Exos-MNs系统应用的最新进展，并讨论了其临床翻译的未来前景和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

24 days

期刊介绍： International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.