Eco-friendly biosynthesis of nickel oxide nanoparticles and investigation of its antibacterial and toxicological assessment

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2025-07-16 DOI:10.1016/j.jics.2025.101946

Mahpara Jabeen , Iqra Nawaz , Rama Qintar , Mahnoor Rahat

{"title":"Eco-friendly biosynthesis of nickel oxide nanoparticles and investigation of its antibacterial and toxicological assessment","authors":"Mahpara Jabeen , Iqra Nawaz , Rama Qintar , Mahnoor Rahat","doi":"10.1016/j.jics.2025.101946","DOIUrl":null,"url":null,"abstract":"<div><div>Green synthesis of metal oxide nanoparticles is an emerging field of research that enhances the dispersion and stability of the NPs. The NiONPs were synthesized using the <em>Butea monosperma gum</em> extract as a reducing, potential stabilizing and chelating agent. The size, morphology, crystallinity and shape of synthesized nanoparticles were studied by using characterization methods Zetasizer, UV–Vis, XRD, FTIR, (SEM), and photoluminescence spectroscopy (PL). NiONPs show a face-centered cubic crystalline structure in their XRD Spectra. UV–visible examination revealed a band in between 250 and 300 nm and it shows an optical band gap is 3.2eV, indicating the synthesis of NiONPs. The luminescence emission peaks appeared at 351, 440, 486, and 530 nm. The morphological features of nickel oxide nanoparticles are slightly agglomerated and then size of green synthesized NiONPs as found in between 20 and 22 nm. The antibacterial activity of NiONPs were show significant inhibitory activity against different bacterial strains. The area of inhibition for <em>Bacillus subtilis</em> was observed (12.3 ± 0.4) mm and for <em>Staphylococcus aureus</em> observed (15.3 ± 0.4) mm showed good antibacterial potential of synthesized NiONPs. Furthermore, on human erythrocytes, NiONPs have essential non-toxic characteristics, and they interfere with the coagulation cascade's activity in both PRP and PPP on human blood. The NiONPs synthesized through the proposed methodology could be of great benefit for further clinical trials, drug designing and wastewater treatment.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 9","pages":"Article 101946"},"PeriodicalIF":3.2000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Indian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0019452225003814","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Green synthesis of metal oxide nanoparticles is an emerging field of research that enhances the dispersion and stability of the NPs. The NiONPs were synthesized using the Butea monosperma gum extract as a reducing, potential stabilizing and chelating agent. The size, morphology, crystallinity and shape of synthesized nanoparticles were studied by using characterization methods Zetasizer, UV–Vis, XRD, FTIR, (SEM), and photoluminescence spectroscopy (PL). NiONPs show a face-centered cubic crystalline structure in their XRD Spectra. UV–visible examination revealed a band in between 250 and 300 nm and it shows an optical band gap is 3.2eV, indicating the synthesis of NiONPs. The luminescence emission peaks appeared at 351, 440, 486, and 530 nm. The morphological features of nickel oxide nanoparticles are slightly agglomerated and then size of green synthesized NiONPs as found in between 20 and 22 nm. The antibacterial activity of NiONPs were show significant inhibitory activity against different bacterial strains. The area of inhibition for Bacillus subtilis was observed (12.3 ± 0.4) mm and for Staphylococcus aureus observed (15.3 ± 0.4) mm showed good antibacterial potential of synthesized NiONPs. Furthermore, on human erythrocytes, NiONPs have essential non-toxic characteristics, and they interfere with the coagulation cascade's activity in both PRP and PPP on human blood. The NiONPs synthesized through the proposed methodology could be of great benefit for further clinical trials, drug designing and wastewater treatment.

查看原文本刊更多论文

纳米氧化镍的生态合成及其抗菌和毒理学评价研究

绿色合成金属氧化物纳米粒子是一个新兴的研究领域，提高纳米粒子的分散性和稳定性。以丁茶单精子胶提取物为还原剂、潜在稳定剂和螯合剂合成了NiONPs。采用Zetasizer、UV-Vis、XRD、FTIR、SEM和光致发光光谱（PL）等表征方法对合成的纳米颗粒的大小、形貌、结晶度和形状进行了研究。NiONPs的XRD光谱显示为面心立方晶体结构。在250 ~ 300 nm范围内有一个带，光学带隙为3.2eV，表明合成了NiONPs。发光峰出现在351,440,486和530 nm处。氧化镍纳米颗粒的形态特征是微团聚，合成的绿色NiONPs的尺寸在20 ~ 22 nm之间。NiONPs对不同菌株的抑菌活性均有显著的抑制作用。合成的NiONPs对枯草芽孢杆菌的抑菌面积为（12.3±0.4）mm，对金黄色葡萄球菌的抑菌面积为（15.3±0.4）mm。此外，在人红细胞中，NiONPs具有基本的无毒特性，并且它们会干扰人血液中PRP和PPP的凝血级联活性。通过所提出的方法合成的NiONPs对进一步的临床试验、药物设计和废水处理有很大的好处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.