Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy.

Smart molecules : open access Pub Date : 2024-11-13 eCollection Date: 2025-06-01 DOI:10.1002/smo.20240035
Wenhua Jia, Junqing Wang, Ling Li, Qiong Yuan, Yuze Wang, Xinyi Zhang, Yanli Tang
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Abstract

Sonodynamic therapy (SDT) is garnering considerable attention as a promising treatment for deep-seated tumors because of its strong tissue penetration ability, non-invasiveness, and controllability. However, the SDT efficiency of traditional sonosensitizers including porphyrins and their derivatives are limited due to their poor water dissolubility, high aggregation, and low reactive oxygen species (ROS) production efficiency. Consequently, it is crucial to develop novel sonosensitizers with high yields of ROS, outstanding water solubility, and good biocompatibility. Herein, we constructed a new platform for SDT based on unimolecular porphyrin derivatives OPV-C3-TPP. The probe OPV-C3-TPP was synthesized by covalently linking conjugated oligomers (OPV) with 5, 10, 15, 20-tetra (4-aminophenyl) porphyrin (TAPP). The introduction of OPV greatly improves the water solubility of the porphyrins and reduces the self-aggregation of the porphyrins. In addition, OPV-C3-TPP has good intramolecular energy transfer efficiency, thus enhancing the yield of ROS. The experimental results show that OPV-C3-TPP exhibits excellent ROS generation capacity under ultrasound (US) irradiation, which leads to apoptosis and necrosis of tumor cells. In vivo tumor growth is also significantly inhibited in the OPV-C3-TPP + US group, exhibiting better SDT effects than TAPP. Therefore, the unimolecular OPV-C3-TPP can be used as a potential sonosensitizer, providing a promising SDT for deep-tissue tumors.

用于声动力治疗的共轭低聚(苯基乙烯基)共价连接卟啉。
声动力疗法(SDT)因其强大的组织穿透能力、无创性和可控性而成为深部肿瘤的一种有前景的治疗方法,正受到越来越多的关注。然而,包括卟啉及其衍生物在内的传统声敏剂由于其水溶性差、高聚集性和低活性氧(ROS)产生效率而受到限制。因此,开发具有高活性氧产量、出色的水溶性和良好的生物相容性的新型声敏剂至关重要。本文基于单分子卟啉衍生物OPV-C3-TPP构建了一个新的SDT平台。以共轭低聚物(OPV)与5,10,15,20 -四(4-氨基苯基)卟啉(TAPP)共价连接,合成了探针OPV- c3 - tpp。OPV的引入大大提高了卟啉的水溶性,降低了卟啉的自聚集。此外,OPV-C3-TPP具有良好的分子内能量转移效率,从而提高了ROS的产率。实验结果表明,OPV-C3-TPP在超声(US)照射下表现出良好的ROS生成能力,导致肿瘤细胞凋亡和坏死。OPV-C3-TPP + US组体内肿瘤生长也明显受到抑制,显示出比TAPP更好的SDT效果。因此,单分子OPV-C3-TPP可作为一种潜在的声敏剂,为深部组织肿瘤的SDT治疗提供了一种很有前景的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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