Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study

IF 4.7 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2025-07-17 DOI:10.1002/oby.24339

Amy E. Taylor, John Vincent, Dylan M. Williams, Rachel Cooper, Snehal M. Pinto Pereira

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引用次数: 0

Abstract

Objective

Our objective was to investigate causal associations of adiposity in different locations and metabolically favorable and unfavorable adiposity (MetFA and MetUFA, respectively) with grip strength.

Methods

Observational cross-sectional and Mendelian randomization (MR) (sex combined and stratified) analysis within UK Biobank (N ≤ 340,258) was used to assess the relationships of visceral, abdominal subcutaneous, and gluteofemoral adipose tissue, anterior and posterior thigh muscle fat infiltration (ATMFI and PTMFI, respectively), body fat (BF) percentage, MetFA, and MetUFA with grip strength.

Results

In inverse variance weighted MR analysis, SD increases in BF, MetFA, and ATMFI were associated with lower grip strength by the following: −0.10 SD (95% CI: −0.16 to −0.04), −0.31 SD (95% CI: −0.45 to −0.18), and −0.05 SD (95% CI: −0.09 to −0.01), respectively. PTMFI associations aligned with ATMFI. Observational analyses were consistent for BF and ATMFI/PTMFI, but weighted median/mode MR corroborated findings for MetFA and ATMFI/PTMFI only. Higher visceral adipose tissue was associated with lower grip strength in observational analyses only. Associations for higher abdominal subcutaneous adipose tissue were inconsistent: Observational analyses suggested weaker grip; MR analyses suggested stronger grip, particularly in female individuals. There was no strong evidence in MR for associations with MetUFA or gluteofemoral adipose tissue.

Conclusions

Targeting fat infiltration in muscle may improve muscle function. MetFA appears to negatively impact muscle strength, requiring further investigation into underlying mechanisms.

Abstract Image

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握力：某些肥胖表型比其他肥胖表型更有害吗？孟德尔随机化研究。

目的：我们的目的是调查不同部位的肥胖以及代谢有利和不利的肥胖（分别为MetFA和MetUFA）与握力的因果关系。方法：在UK Biobank （N≤340,258）中使用观察性横断面和孟德尔随机化（MR）（性别结合和分层）分析来评估内脏、腹部皮下和臀股脂肪组织、大腿前后肌脂肪浸润（分别为ATMFI和PTMFI）、体脂（BF）百分比、MetFA和MetUFA与握力的关系。结果：在反方差加权MR分析中，BF、MetFA和ATMFI的SD增加与握力降低相关，分别为-0.10 SD （95% CI: -0.16至-0.04）、-0.31 SD （95% CI: -0.45至-0.18）和-0.05 SD （95% CI: -0.09至-0.01）。PTMFI协会与ATMFI一致。观察性分析与BF和ATMFI/PTMFI一致，但加权中位数/模式MR仅证实了MetFA和ATMFI/PTMFI的结果。在观察性分析中，较高的内脏脂肪组织与较低的握力有关。高腹部皮下脂肪组织的相关性不一致：观察分析表明握力较弱；核磁共振分析表明握力更强，尤其是女性。磁共振检查没有强有力的证据表明与MetUFA或臀股脂肪组织有关。结论：靶向脂肪浸润肌肉可改善肌肉功能。MetFA似乎对肌肉力量有负面影响，需要进一步研究其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.