Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial.

Obesity (Silver Spring, Md.) Pub Date : 2025-07-16 DOI:10.1002/oby.24354

Mansour Alblaji, Stuart R Gray, Taibah Almesbehi, Douglas J Morrison, Dalia Malkova

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Abstract

Objective: To investigate the effect of krill oil (KO) supplementation during alternate-day fasting (ADF) on body composition and muscle function in healthy adults with overweight.

Methods: In a randomized trial, during the 8-week ADF, participants consumed four capsules per day containing krill oil (KO group) or vegetable oil (placebo group). Each capsule of KO contained 191 mg EPA, 94 mg DHA, 78 mg choline, and 100 mcg astaxanthin. Body mass, fat-free mass (FFM), and handgrip strength (HGS) were measured before and after the intervention. Data were analyzed using ANOVA.

Results: The study was completed by 41 (25 women and 16 men) participants (age: 39 ± 10 years, BMI: 31.1 ± 4.2 kg/m²). Body weight reduction was not different (p > 0.05) between groups (KO, -4.6 ± 1.4 kg; Placebo, -4.5 ± 1.9 kg). The KO group had no change (p > 0.05) in FFM (-0.2 ± 0.9 kg) or HGS (-0.2 ± 0.5 kg). The placebo group experienced a reduction (p < 0.05) in FFM (-1.2 ± 2.0 kg) and HGS (-0.9 ± 0.7 kg). Changes in FFM and HGS were different (p < 0.05) between groups.

Conclusions: KO supplementation during body weight loss attenuates the decline in FFM and muscle strength.

Trial registration: ClinicalTrials.gov Identifier (NCT06001632).

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在超重和肥胖成人隔日禁食期间补充磷虾油的益处：一项随机试验。

目的：探讨禁食期间补充磷虾油（KO）对超重健康成人体成分和肌肉功能的影响。方法：在一项随机试验中，在8周ADF期间，参与者每天服用4粒含有磷虾油（KO组）或植物油（安慰剂组）的胶囊。每粒KO胶囊含有191毫克EPA， 94毫克DHA， 78毫克胆碱和100毫克虾青素。测量干预前后的体质量、无脂质量（FFM）和握力（HGS）。数据分析采用方差分析。结果：41名参与者（女性25名，男性16名）完成研究，年龄：39±10岁，BMI: 31.1±4.2 kg/m2。各组间体重减轻量差异无统计学意义（p < 0.05） (KO, -4.6±1.4 kg；安慰剂，-4.5±1.9 kg)。KO组FFM（-0.2±0.9 kg）和HGS（-0.2±0.5 kg）无显著差异（p < 0.05）。结论：体重减轻期间补充KO可减轻FFM和肌肉力量的下降。试验注册：ClinicalTrials.gov标识符（NCT06001632）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Obesity (Silver Spring, Md.)

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