FAP-α in soft tissue and bone sarcomas: A new potential diagnostic and therapeutic biomarker in the era of precision medicine

Abstract

Fibroblast activation protein alpha (FAP-α) is a membrane-bound serine protease expressed by mesenchymal cells within the tumor microenvironment. It has garnered significant attention due to its involvement in tumorigenesis in several neoplasms, with a specific attention in sarcomas due to their mesenchymal origin. In this review, the authors explore the biological functions of FAP-α and its implications in sarcoma pathophysiology. Understanding the potential applicability of FAP-α as a diagnostic and therapeutic target in sarcoma could provide new avenues for targeted therapies and improve patient outcomes.