Evaluating the Effectiveness of Spousal Testing Among Syphilis-Infected Pregnant Women in the Context of Mother-to-Child Transmission Elimination: A Multicenter Study in Southeastern China.

IF 2 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Risk Management and Healthcare Policy Pub Date : 2025-07-12 eCollection Date: 2025-01-01 DOI:10.2147/RMHP.S531584

Xiaomeng Xue, Xinxin Huang, Guihua Liu, Xiumin Jiang, Wenzhao Lin, Yongfan Chen, Chengyu Huang

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Abstract

Purpose: Syphilis during pregnancy poses significant risks to maternal and neonatal health. Spousal testing is crucial for preventing congenital syphilis transmission. This study assessed spousal testing rates among syphilis-positive pregnant women to guide public health interventions.

Methods: This multicenter effectiveness study was conducted in Southeast China, utilizing data from the Chinese HIV/AIDS, Syphilis, and Hepatitis B Prevention Information System between 2018 to 2024. Proportions were used to describe the sociodemographic characteristics of pregnant women with syphilis. Univariate and multivariate unconditional logistic regression models were used to analyze the factors associated with the testing status of spouses of pregnant women with syphilis.

Results: A total of 4,875 spouses were tested for syphilis. Older gestational age at the first prenatal visit (aOR = 1.014, 95% CI: 1.007-1.022) and at delivery (aOR = 1.273, 95% CI: 1.011-1.602) were associated with lower rates of spousal testing. Spouses of women reported in 2022-2023 (aOR = 1.840, 95% CI: 1.465-2.311) had a higher likelihood of being untested. Unmarried status (aOR = 1.181, 95% CI: 1.022-1.364), junior high school education and below (aOR = 1.244, 95% CI: 1.121-1.381), no history of infection (aOR = 2.281, 95% CI: 2.073-2.510), and prenatal care in Grade II hospitals (aOR = 0.1.292, 95% CI: 1.140-1.464) were risk factors for spousal testing.

Conclusion: From 2018 to 2024, the spousal testing rate was 60%, with a syphilis positivity rate of 14.7%. Data revealed multiple risk factors, such as a late first pregnancy test, advanced age, unmarried status, lower education level, no history of syphilis infection, and selection of prenatal care in Grade II hospitals as delivery facilities. Recommendations include establishing specialized clinics, post-test spousal counseling, and routine spousal testing.

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在消除母婴传播的背景下评估配偶检测对感染梅毒孕妇的有效性：一项中国东南部的多中心研究。

目的：妊娠期梅毒对孕产妇和新生儿健康构成重大风险。配偶检测对预防先天性梅毒传播至关重要。本研究评估梅毒阳性孕妇的配偶检测率，以指导公共卫生干预。方法：本多中心有效性研究在中国东南部开展，利用2018 - 2024年中国HIV/AIDS、梅毒和乙型肝炎预防信息系统的数据。用比例来描述梅毒孕妇的社会人口学特征。采用单因素和多因素无条件logistic回归模型分析梅毒孕妇配偶检测状况的相关因素。结果：共有4875对配偶进行了梅毒检测。首次产前检查时胎龄较大（aOR = 1.014, 95% CI: 1.007-1.022）和分娩时（aOR = 1.273, 95% CI: 1.011-1.602）与配偶检测率较低相关。2022-2023年报告的女性配偶（aOR = 1.840, 95% CI: 1.465-2.311）未接受检测的可能性更高。未婚（aOR = 1.181, 95% CI: 1.022 ~ 1.364）、初中及以下学历（aOR = 1.244, 95% CI: 1.121 ~ 1.381）、无感染史（aOR = 2.281, 95% CI: 2.073 ~ 2.510）、二级医院产前护理（aOR = 0.1.292, 95% CI: 1.140 ~ 1.464）是配偶检测的危险因素。结论：2018 - 2024年，配偶检测率为60%，梅毒阳性率为14.7%。数据显示多重危险因素，如首次妊娠试验晚、高龄、未婚、文化程度低、无梅毒感染史、选择二级医院产前护理作为分娩设施等。建议包括建立专门的诊所，测试后的配偶咨询，以及常规的配偶检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Risk Management and Healthcare Policy Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.20

自引率

2.90%

发文量

242

审稿时长

16 weeks

期刊介绍： Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include: Public and community health Policy and law Preventative and predictive healthcare Risk and hazard management Epidemiology, detection and screening Lifestyle and diet modification Vaccination and disease transmission/modification programs Health and safety and occupational health Healthcare services provision Health literacy and education Advertising and promotion of health issues Health economic evaluations and resource management Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.