Association Between Weight-Adjusted Waist Circumference Index and Metabolic Disease-Associated Fatty Liver Disease: A Retrospective Study.

IF 2.7 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Risk Management and Healthcare Policy Pub Date : 2025-07-12 eCollection Date: 2025-01-01 DOI:10.2147/RMHP.S524872

Ting Tang, Hua Fan, Qingwen Yu, Xiyun Rao, Yongmin Shi, Xuhan Tong, Lanlan Feng, Zhao Xu, Xinyan Fu, Juan Chen, Xingwei Zhang, Jiake Tang, Hu Wang, Mingwei Wang

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引用次数: 0

Abstract

Background: Metabolic disease-associated fatty liver disease has brought significant challenges to public health and social-economics. There is a need for a straightforward and effective method to screen for metabolic disease-associated fatty liver disease. The weight-adjusted waist circumference index offers a comprehensive reflection of visceral fat accumulation and skeletal muscle loss. This study aims to explore the relationship between weight-adjusted waist circumference index and hepatic steatosis and hepatic fibrosis.

Methods: This single-centered study screened 288 participants from the outpatient department of the Affiliated Hospital of Hangzhou Normal University (Hangzhou, China). Multiple linear regression models were utilized to assess the association between weight-adjusted waist circumference index and hepatic steatosis and hepatic fibrosis. The subgroup analysis was carried out according to sex, smoking, drinking, BMI, cardiovascular disease, diabetes and hypertension.

Results: Metabolic disease-associated fatty liver disease was diagnosed in 185 out of 288 patients. Multivariate linear regression analysis indicated a positive linear correlation between weight-adjusted waist circumference index and hepatic steatosis and hepatic fibrosis (P < 0.05). Analysis of subgroups revealed a stronger positive correlation between weight-adjusted waist circumference index and controlled attenuation parameter among participants aged 18-59 years and smokers (P < 0.05). Positive correlations between weight-adjusted waist circumference index and hepatic fibrosis were observed in participants who were alcohol consumers, male, had a body mass index of >28, and with diabetes (P < 0.05).

Conclusion: We report a significant linear positive correlation between weight-adjusted waist circumference index and metabolic disease-associated fatty liver disease, suggesting that weight-adjusted waist circumference index is a potential indicator for metabolic disease-associated fatty liver disease screening.

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体重调整腰围指数与代谢性疾病相关脂肪肝的相关性：一项回顾性研究

背景：代谢性疾病相关的脂肪肝给公共卫生和社会经济学带来了重大挑战。需要一种简单有效的方法来筛查代谢性疾病相关的脂肪肝。体重调整后的腰围指数可以全面反映内脏脂肪的积累和骨骼肌的损失。本研究旨在探讨体重调节腰围指数与肝脂肪变性及肝纤维化的关系。方法：本单中心研究从杭州师范大学附属医院（中国杭州）门诊部筛选288名受试者。采用多元线性回归模型评估体重校正腰围指数与肝脂肪变性和肝纤维化之间的关系。根据性别、吸烟、饮酒、BMI、心血管疾病、糖尿病和高血压进行亚组分析。结果：288例患者中有185例诊断为代谢性疾病相关脂肪肝。多因素线性回归分析显示体重校正腰围指数与肝脂肪变性、肝纤维化呈正相关（P < 0.05）。亚组分析显示，18-59岁及吸烟人群体重调整腰围指数与控制衰减参数之间存在较强的正相关（P < 0.05）。体重调整后的腰围指数与肝纤维化正相关的研究对象为饮酒、男性、体重指数为bbb28、糖尿病患者（P < 0.05）。结论：体重调整腰围指数与代谢性疾病相关脂肪性肝病之间存在显著的线性正相关，提示体重调整腰围指数可作为代谢性疾病相关脂肪性肝病筛查的潜在指标。

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来源期刊

Risk Management and Healthcare Policy Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.20

自引率

2.90%

发文量

242

审稿时长

16 weeks

期刊介绍： Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include: Public and community health Policy and law Preventative and predictive healthcare Risk and hazard management Epidemiology, detection and screening Lifestyle and diet modification Vaccination and disease transmission/modification programs Health and safety and occupational health Healthcare services provision Health literacy and education Advertising and promotion of health issues Health economic evaluations and resource management Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.