Balancing Vitamin B6 Homeostasis for Plant Immunity.

IF 5.4 2区生物学 Q1 PLANT SCIENCES

Physiologia plantarum Pub Date : 2025-07-01 DOI:10.1111/ppl.70415

Leeza Tariq, Yan Bi, Hui Wang, Mengmeng Guo, Fengming Song

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引用次数: 0

Abstract

Vitamin B6 (VB6), a metabolic cofactor, is essential for plants, animals, and microorganisms. VB6 has emerged as an important regulator of plant immunity, modulating various immune responses, including basal immunity, stomatal defence, and induced systemic resistance. However, the role of VB6 in systemic acquired resistance (SAR) and the active VB6 vitamers involved in modulating plant immunity remain unclear. A recent study reveals that Δ1-piperideine-6-carboxylic acid (P6C), a metabolite from lysine catabolism, sequesters VB6 vitamers, such as pyridoxal (PL) and pyridoxal 5'-phosphate (PLP), into inert complexes. This depletion of active VB6 vitamers disrupts VB6 homeostasis, impairing SAR, while exogenous application of VB6 restores resistance. Interestingly, the resemblance of this mechanism to pyridoxine-dependent epilepsy in humans suggests evolutionary conservation of these metabolic processes. This article explores the multifaceted roles of VB6 in different aspects of plant immunity. We emphasise the need for further research to decode the complex interplay between VB6 homeostasis and defence hormone pathways to deepen our understanding of immune signalling and develop new strategies to enhance stress resilience in plants.

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平衡维生素B6对植物免疫的体内平衡。

维生素B6 （VB6）是一种代谢辅助因子，对植物、动物和微生物都是必需的。VB6已成为植物免疫的重要调节因子，可调节多种免疫反应，包括基础免疫、气孔防御和诱导的全身抗性。然而，VB6在系统性获得性抗性（SAR）中的作用以及活性VB6维生素参与调节植物免疫的作用尚不清楚。最近的一项研究表明，Δ1-piperideine-6-carboxylic酸（P6C），赖氨酸分解代谢的代谢物，将VB6维生素，如吡哆醛（PL）和吡哆醛5'-磷酸（PLP），隔离成惰性配合物。这种活性维生素VB6的消耗破坏了VB6的体内平衡，损害了SAR，而外源应用VB6可以恢复抵抗力。有趣的是，这种机制与人类吡哆醇依赖性癫痫的相似性表明这些代谢过程的进化守恒。本文探讨了VB6在植物免疫不同方面的多方面作用。我们强调需要进一步的研究来解码VB6稳态和防御激素途径之间复杂的相互作用，以加深我们对免疫信号的理解，并开发新的策略来增强植物的应激恢复能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiologia plantarum 生物-植物科学

CiteScore

11.00

自引率

3.10%

发文量

224

审稿时长

3.9 months

期刊介绍： Physiologia Plantarum is an international journal committed to publishing the best full-length original research papers that advance our understanding of primary mechanisms of plant development, growth and productivity as well as plant interactions with the biotic and abiotic environment. All organisational levels of experimental plant biology – from molecular and cell biology, biochemistry and biophysics to ecophysiology and global change biology – fall within the scope of the journal. The content is distributed between 5 main subject areas supervised by Subject Editors specialised in the respective domain: (1) biochemistry and metabolism, (2) ecophysiology, stress and adaptation, (3) uptake, transport and assimilation, (4) development, growth and differentiation, (5) photobiology and photosynthesis.