Predischarge Betamethasone in Infants Diagnosed With Bronchopulmonary Dysplasia.

IF 2.7 3区 医学 Q1 PEDIATRICS
Tal-El Ernest, Doreen Ozalvo, Orna Staretz-Chacham, Kyla A Marks, Eilon Shany, Daniela Landau, Justin Richardson
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Abstract

Background: The aim of this study was to assess the influence of a short betamethasone therapy course for infants diagnosed with BPD on the need of oxygen therapy after discharge home, on post-menstrual age (PMA) discharge, and on hospital readmission rates.

Methods: This was a retrospective cohort study that included infants born and diagnosed with BPD in the Soroka University Medical Center neonatal department between 2012 and 2020. Demographic and clinical parameters were extracted from computerized medical files.

Results: Overall, 187 infants were included in the study; 151 (81%) were treated with betamethasone, of them 110 (73%) were discharged home without supplemental oxygen. Nonsignificant differences were found between infants treated with or without betamethasone regarding home oxygen supplementation at discharge (27% treated vs. 17% without, p = 0.192) and PMA at discharge (40.2 weeks treated vs. 41.2 weeks not treated, p = 0.114). Of the infants receiving betamethasone, those weaned from oxygen were discharged home at an earlier PMA (39.6 ± 5.0 vs. 42.0 ± 3.7 week, p < 0.001) and there was no difference between readmission rates due to respiratory problems of infants discharged home without oxygen supplementation to those discharged with oxygen (37/108 [34%] vs. 14/36 [39%], p = 0.615). In multivariable analysis, respiratory support at 36 weeks PMA (odds ratio: 4.4 [CI: 1.5-13.2], p < 0.009) and receiving two or more courses of betamethasone (odds ratio: 3.6 [CI: 1.2-10.5], p = 0.009) were significant predictors for need of oxygen supplementation at discharge.

Conclusions: Use of corticosteroids for infants diagnosed with BPD may shorten hospital stay by promoting weaning from oxygen therapy.

出院前使用倍他米松治疗支气管肺发育不良的婴儿。
背景:本研究的目的是评估短时间倍他米松治疗对诊断为BPD的婴儿出院后氧疗需求、经后年龄(PMA)出院和再入院率的影响。方法:这是一项回顾性队列研究,包括2012年至2020年间在Soroka大学医学中心新生儿科出生并诊断为BPD的婴儿。从计算机化的医疗档案中提取人口学和临床参数。结果:187名婴儿被纳入研究;使用倍他米松治疗151例(81%),其中110例(73%)出院时不补充氧气。接受或不接受倍他米松治疗的婴儿在出院时的家庭补氧(接受治疗的婴儿占27%,未接受治疗的婴儿占17%,p = 0.192)和出院时的PMA(接受治疗的婴儿占40.2周,未接受治疗的婴儿占41.2周,p = 0.114)差异无统计学意义。在接受倍他米松治疗的婴儿中,停用氧的婴儿在更早的PMA(39.6±5.0 vs 42.0±3.7周)出院回家。结论:对诊断为BPD的婴儿使用皮质类固醇可通过促进停用氧治疗缩短住院时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pediatric Pulmonology
Pediatric Pulmonology 医学-呼吸系统
CiteScore
6.00
自引率
12.90%
发文量
468
审稿时长
3-8 weeks
期刊介绍: Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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