Erin D. Anderson , Daunel V. Augustin , Anastasia P. Georges , David A. Issadore , David F. Meaney
{"title":"Brain biomarker profiles vary with semi-synthetic and grain-based diets in healthy and mTBI mice","authors":"Erin D. Anderson , Daunel V. Augustin , Anastasia P. Georges , David A. Issadore , David F. Meaney","doi":"10.1016/j.neulet.2025.138318","DOIUrl":null,"url":null,"abstract":"<div><div>Across a range of neurological disorders, there is a growing appreciation for how the gut influences brain health, but few ways of monitoring its effects. Although nutrition influences traumatic brain injury (TBI) recovery, its influence on biomarkers—whether as an intervention or confounder—is poorly understood. Beyond specialized diets, standard rodent diets may also affect brain function. Neuron-derived extracellular vesicles (NDEVs) offer a brain-specific complement to circulating biomarkers, but their sensitivity to diet is unknown. In this study, we isolated miRNAs from NDEVs from the serum of healthy and mild TBI (mTBI) mice fed a semi-synthetic or grain-based diet. NDEV miRNAs encoded dietary differences based on injury condition, suggesting that NDEVs are sensitive to dietary changes and may be able to track diet’s effect on TBI recovery. Additionally, we found that diet influenced injury biomarkers, underscoring diet as a confounding variable for NDEV miRNA biomarkers. Together, these findings highlight NDEVs as a promising tool for monitoring the effects of subtle dietary differences on brain health and the importance of diet reporting to improve study reproducibility.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138318"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience Letters","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S030439402500206X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Across a range of neurological disorders, there is a growing appreciation for how the gut influences brain health, but few ways of monitoring its effects. Although nutrition influences traumatic brain injury (TBI) recovery, its influence on biomarkers—whether as an intervention or confounder—is poorly understood. Beyond specialized diets, standard rodent diets may also affect brain function. Neuron-derived extracellular vesicles (NDEVs) offer a brain-specific complement to circulating biomarkers, but their sensitivity to diet is unknown. In this study, we isolated miRNAs from NDEVs from the serum of healthy and mild TBI (mTBI) mice fed a semi-synthetic or grain-based diet. NDEV miRNAs encoded dietary differences based on injury condition, suggesting that NDEVs are sensitive to dietary changes and may be able to track diet’s effect on TBI recovery. Additionally, we found that diet influenced injury biomarkers, underscoring diet as a confounding variable for NDEV miRNA biomarkers. Together, these findings highlight NDEVs as a promising tool for monitoring the effects of subtle dietary differences on brain health and the importance of diet reporting to improve study reproducibility.
期刊介绍:
Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.