Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Lisa A Peterson, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Bart Heldreth
{"title":"Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics.","authors":"Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Lisa A Peterson, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Bart Heldreth","doi":"10.1177/10915818251343874","DOIUrl":null,"url":null,"abstract":"<p><p>The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm<sup>2</sup>. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.</p>","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":"44 2_suppl","pages":"103S-123S"},"PeriodicalIF":1.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10915818251343874","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/17 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.
期刊介绍：
The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Review Expert Panel.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
