Hippo/YAP signaling's multifaceted crosstalk in cancer.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1595362

Jie Zhang, Haipeng Wu, Xinxin Ren, Zhuoshi Chen, Siyu Ye, Shuchang Chen, Jie Fang, Qirou Wu, Tiejun Zhao

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Abstract

The Hippo/yes-associated protein (YAP) signaling is an evolutionarily conserved regulator in organ size control, which plays pivotal roles in cell proliferation, differentiation, apoptosis, and tissue regeneration. In cancer, dysregulation of Hippo/YAP signaling is typically recognized as one of the crucial drivers in tumorigenesis. However, beyond its canonical transcriptional targets, Hippo/YAP signaling engages in extensive crosstalk with multiple pathways to form an intricate regulatory network, thereby giving rise to its content-dependent influence on tumor initiation, progression and metastasis. This review focuses on the molecular mechanisms underlying the interplay between Hippo/YAP and pivotal signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), wingless-type (Wnt)/β-catenin signaling pathway, transforming growth factor-beta (TGF-β), Hedgehog, Notch and other signaling pathways, as well as their implications in cancer biology. Ultimately, exploiting these mechanisms may represent promising therapeutic strategies for cancer.

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Hippo/YAP信号在癌症中的多面串扰。

Hippo/yes-associated protein （YAP）信号是一种进化保守的器官大小调控因子，在细胞增殖、分化、凋亡和组织再生中起关键作用。在癌症中，Hippo/YAP信号的失调通常被认为是肿瘤发生的关键驱动因素之一。然而，除了其典型的转录靶点外，Hippo/YAP信号还与多种途径进行广泛的串扰，形成复杂的调控网络，从而对肿瘤的发生、进展和转移产生内容依赖性的影响。本文就Hippo/YAP与活化B细胞核因子κB轻链增强子（NF-κB）、无翼型(Wnt)/β-catenin信号通路、转化生长因子β (TGF-β)、Hedgehog、Notch等关键信号通路相互作用的分子机制及其在肿瘤生物学中的意义进行综述。最终，利用这些机制可能代表有希望的癌症治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.