Insulin/insulin-like growth factor signaling pathway promotes higher fat storage in Drosophila females.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-07-15 DOI:10.1016/j.celrep.2025.115915

Puja Biswas, Jennifer A Bako, J Beatrice Liston, Huaxu Yu, Lianna W Wat, Colin J Miller, Michael D Gordon, Tao Huan, Molly Stanley, Elizabeth J Rideout

引用次数: 0

Abstract

In Drosophila, adult females store more fat than males. While the mechanisms that restrict body fat in males are becoming clearer, less is known about how females achieve higher fat storage. Here, we perform a detailed investigation of the mechanisms that promote higher fat storage in females. We show that a greater intake of dietary sugar supports higher fat storage due to female-biased remodeling of the fat body lipidome. Dietary sugar stimulates a female-specific increase in Drosophila insulin-like peptide 3 (Dilp3), which acts together with greater peripheral insulin sensitivity to augment insulin/insulin-like growth factor signaling pathway (IIS) activity in adult females. Indeed, Dilp3 overexpression prevented the female-biased decrease in body fat after removal of dietary sugar. Given that adult-specific IIS inhibition caused a female-biased decrease in body fat, our data reveal IIS as a key determinant of female fat storage.

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胰岛素/胰岛素样生长因子信号通路促进雌性果蝇更高的脂肪储存。

在果蝇中，成年雌性比雄性储存更多的脂肪。虽然限制男性体脂的机制越来越清晰，但对于女性如何获得更高的脂肪储存却知之甚少。在这里，我们对促进女性脂肪储存的机制进行了详细的调查。我们表明，由于女性偏向于脂肪体脂质组的重塑，摄入更多的膳食糖支持更高的脂肪储存。饮食中的糖刺激果蝇胰岛素样肽3 （Dilp3）的雌性特异性增加，Dilp3与更大的外周胰岛素敏感性一起作用，增强成年雌性胰岛素/胰岛素样生长因子信号通路（IIS）的活性。事实上，Dilp3的过度表达阻止了在去除饮食中的糖后，女性倾向的体脂减少。鉴于成人特异性IIS抑制导致女性偏向体脂减少，我们的数据显示IIS是女性脂肪储存的关键决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.