Seasonal Incidence of Human Metapneumovirus in High-Risk Adults With Medically Attended Acute Respiratory Illness in a Rural US Community

IF 4.2 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-07-17 DOI:10.1111/irv.70119

Maria E. Sundaram, David L. McClure, Oluwakemi D. Alonge, Jennifer P. King, Jennifer K. Meece, Huong Q. Nguyen

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Abstract

Background

The burden of human metapneumovirus (hMPV) among community-dwelling high-risk adults is understudied. We calculate the cumulative incidence of outpatient hMPV in high-risk adults, over five consecutive winter respiratory virus seasons (2015–2016 through 2019–2020), and describe clinical characteristics of their illnesses.

Methods

We conducted a retrospective analysis of data and respiratory specimens from adults ≥ 18 years old originally participating in a test-negative study of influenza vaccine effectiveness. We included adults with ≥ 1 high-risk condition in 2015–2016 through 2019–2020 seasons. Residual respiratory specimens were retested for hMPV using a multiplex viral panel. We calculated seasonal incidence using Poisson regression and population weighting, with the sum of observed and extrapolated hMPV cases in the study cohort divided by the number of adults with high-risk conditions in the underlying source population.

Results

We tested 3601 respiratory samples; the mean (SD) age of individuals contributing samples was 53 (19) years. We identified 289 individuals (8.0%) with a respiratory sample positive for human metapneumovirus. The estimated seasonal incidence of outpatient hMPV-associated acute respiratory illness was 95.6 (95% CI: 80.5–113.4) cases per 10,000 high-risk adults. These values varied by season, with the highest incidence in 2015–2016 (276.8 cases per 10,000; 95% CI: 210.7–363.5) and lowest in 2016–17 (55.0 cases per 10,000; 95% CI: 31.2–97.0).

Conclusions

We identified substantial seasonal incidence of hMPV cases in community-dwelling high-risk adults in a Wisconsin population cohort.

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美国农村社区急性呼吸道疾病高危成人中人偏肺病毒的季节性发病率

背景目前对社区高危成人人偏肺病毒（hMPV）感染负担的研究尚不充分。我们计算了连续5个冬季呼吸道病毒季节（2015-2016年至2019-2020年）高危成人门诊hMPV的累积发病率，并描述了他们疾病的临床特征。方法我们对最初参与流感疫苗有效性试验阴性研究的≥18岁成人的数据和呼吸道标本进行回顾性分析。我们纳入了2015-2016年至2019-2020年期间有≥1种高危疾病的成年人。使用多重病毒面板重新检测残余呼吸道标本的hMPV。我们使用泊松回归和人群加权计算季节性发病率，将研究队列中观察到的和推断出的hMPV病例的总和除以潜在源人群中具有高危条件的成人人数。结果共检测呼吸道样本3601份；提供样本的个体的平均（SD）年龄为53（19）岁。我们发现289人（8.0%）呼吸道样本呈人偏肺病毒阳性。门诊hmpv相关急性呼吸道疾病的季节性发病率估计为每10,000名高危成人95.6例（95% CI: 80.5-113.4）。这些数值因季节而异，2015-2016年发病率最高(每万人276.8例；95% CI: 210.7-363.5)， 2016 - 2017年最低(每万人55.0例；95% ci: 31.2-97.0)。结论：我们在威斯康辛州人群队列中发现了hMPV病例在社区高危成人中的季节性发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.