Association Between House Dust Endotoxins and Increased All-Cause Mortality in Adults

IF 4.3 2区环境科学与生态学 Q1 CONSTRUCTION & BUILDING TECHNOLOGY

Indoor air Pub Date : 2025-07-16 DOI:10.1155/ina/8885072

Ren Zhou, Zongzong Quan, Yu Sun, Lei Zhang, Jia Yan, Hong Jiang

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Abstract

Background: Exposure to house dust endotoxins is known to cause diseases across various organ systems; however, their effect on mortality remains unclear.

Objective: This study is aimed at investigating the association between house dust endotoxins and mortality in US adults.

Methods: National Health and Nutrition Examination Survey data from 2005 to 2006 were used in this study. Participants were linked to mortality data from the date of the survey through December 31, 2019. A multivariate Cox regression analysis was used to determine the association between house dust endotoxins and mortality. All analyses were performed in the overall population and across different sensitization statuses.

Results: This cohort study included 3171 adults aged 20 years or older (weighted median age (P25–P75): 45 (32–58) years; 49.2% male). Among them, 1287 participants were sensitized to inhalant allergens. During a median follow-up of 13.8 years, 672 deaths occurred. In participants sensitized to inhalant allergens, house dust endotoxins were significantly associated with all-cause mortality. The hazard ratio (HR) comparing the highest and lowest tertiles of house dust endotoxin levels was 1.98 (95% confidence interval (CI): 1.32–2.97) for all-cause mortality. An association was observed between endotoxin concentration and cardiovascular disease mortality when analyzed as a continuous variable (HR: 1.29, 95% CI: 1.01–1.56). In nonsensitized participants, no significant association was found between house dust endotoxins and mortality.

Conclusion: Exposure to house dust endotoxins was associated with all-cause mortality in adults sensitized to inhalant allergens.

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室内灰尘内毒素与成人全因死亡率增加之间的关系

背景：已知暴露于室内灰尘内毒素可引起各种器官系统的疾病；然而，它们对死亡率的影响尚不清楚。目的：本研究旨在调查美国成人室内灰尘内毒素与死亡率之间的关系。方法：采用2005 ~ 2006年全国健康与营养调查资料。参与者与调查日期至2019年12月31日的死亡率数据有关。采用多变量Cox回归分析确定室内灰尘内毒素与死亡率之间的关系。所有的分析都是在总体人群和不同的致敏状态下进行的。结果：该队列研究包括3171名20岁或以上的成年人(加权中位年龄（P25-P75）： 45（32-58）岁；49.2%的男性)。其中，1287名参与者对吸入性过敏原敏感。在平均13.8年的随访期间，发生了672例死亡。在对吸入性过敏原敏感的参与者中，室内灰尘内毒素与全因死亡率显著相关。室内灰尘内毒素水平最高和最低三分位数的全因死亡率风险比（HR）为1.98（95%可信区间（CI）： 1.32-2.97）。当作为一个连续变量进行分析时，内毒素浓度与心血管疾病死亡率之间存在关联（HR: 1.29, 95% CI: 1.01-1.56）。在非敏感的参与者中，没有发现室内灰尘内毒素与死亡率之间的显著关联。结论：吸入性变应原致敏的成人暴露于室内粉尘内毒素与全因死亡率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indoor air 环境科学-工程：环境

CiteScore

10.80

自引率

10.30%

发文量

175

审稿时长

3 months

期刊介绍： The quality of the environment within buildings is a topic of major importance for public health. Indoor Air provides a location for reporting original research results in the broad area defined by the indoor environment of non-industrial buildings. An international journal with multidisciplinary content, Indoor Air publishes papers reflecting the broad categories of interest in this field: health effects; thermal comfort; monitoring and modelling; source characterization; ventilation and other environmental control techniques. The research results present the basic information to allow designers, building owners, and operators to provide a healthy and comfortable environment for building occupants, as well as giving medical practitioners information on how to deal with illnesses related to the indoor environment.