Access to Fully Substituted Furans via Boryl Radical Catalyzed Cycloisomerization of Cyclopropenyl Ketones

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-01 DOI:10.1002/ajoc.202500126

Xingran Yang , Jiahang Li , Prof. Dr. Jinbo Zhao

引用次数: 0

Abstract

We report the boryl radical catalyzed cycloisomerization of cyclopropenyl ketones to fully‐substituted furans, a type of highly important pharmacophore and synthetic intermediate. The reaction features neutral conditions, high yields, and toleration of variation at all possible positions of the substrate, making it an indispensable route for this type of important scaffold. Preliminary downstream transformation also revealed the synthetic potential of these furans in accessing other types of furans or more complex 3D scaffolds.

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硼基自由基催化环丙烯酮环异构化制备全取代呋喃

我们报道了硼基自由基催化环丙烯酮环异构化成完全取代呋喃，这是一种非常重要的药效团和合成中间体。该反应条件中性，产率高，并且在底物的所有可能位置都能耐受变化，使其成为这种重要支架不可缺少的途径。初步的下游转化也揭示了这些呋喃在获取其他类型呋喃或更复杂的3D支架方面的合成潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.