Synchronised Non-Invasive Intermittent Positive Pressure Ventilation in Very Preterm Infants After Birth: A Feasibility Study.

IF 2.4 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2025-07-16 DOI:10.1111/apa.70220

Paul-Philipp Warth, Christoph Martin Rüegger, Vincent David Gaertner, Wolfgang Braun, Kriszta Molnar, Julian Brozek, Christian Friedrich Poets, Laila Springer

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Abstract

Aim: During perinatal transition, breathing effort in preterm infants is largely inefficient. In the current study, we assessed the feasibility of synchronised non-invasive positive pressure ventilation (S-NIPPV) in very preterm infants as primary respiratory support in the delivery room.

Methods: Single-center prospective feasibility study at Tübingen University Hospital. Preterm infants with a gestational age (GA) between 26 and 32 weeks received S-NIPPV during the first 10 min after birth. Synchronisation was achieved using a Graseby capsule; spontaneous breaths were detected by respiratory inductance plethysmography (RIP). Primary outcome was synchronisation rate.

Results: Ten preterm infants with a median GA of 28.8 weeks (IQR 27.6-30.4) and a birth weight of 1028 g (819-1213) were included. S-NIPPV was started within 44 (41-73) seconds after arrival on the resuscitaire. Synchrony rate was 68% (56-76) despite infants being handled significantly and 33% (27-40) of the time interventions were performed.

Conclusion: S-NIPPV as primary respiratory support after birth is feasible with reasonable synchrony, even though infants are frequently stimulated and handled. Future studies are needed to confirm the results of this small pilot study and to determine the effect of S-NIPPV on physiological and clinical outcomes.

Trial registration: Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth (SenSyNoPP); www.

Clinicaltrials: gov: NCT05399914.

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早产儿出生后同步无创间歇正压通气的可行性研究。

目的：围产儿过渡期，早产儿的呼吸努力在很大程度上是无效的。在当前的研究中，我们评估了同步无创正压通气（S-NIPPV）在极早产儿产房中作为主要呼吸支持的可行性。方法：在宾根大学医院进行单中心前瞻性可行性研究。胎龄在26 ~ 32周的早产儿在出生后10分钟内接受S-NIPPV治疗。使用grasby胶囊实现同步；采用呼吸电感容积描记仪（RIP）检测自主呼吸。主要终点为同步率。结果：纳入10例中位GA为28.8周（IQR为27.6-30.4），出生体重为1028 g（819-1213）的早产儿。S-NIPPV在到达复苏器后44（41-73）秒内启动。尽管对婴儿进行了显著处理，但同步率为68%(56-76)，干预时间为33%（27-40）。结论：S-NIPPV作为出生后的主要呼吸支持是可行的，即使婴儿经常受到刺激和处理，但需要合理的同步。需要进一步的研究来证实这一小规模试点研究的结果，并确定S-NIPPV对生理和临床结果的影响。试验注册：早产儿出生后同步无创间歇正压通气（SenSyNoPP）的可行性和可靠性www.Clinicaltrials: gov: NCT05399914。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries