Neonatal Outcomes Among Neonates of Women With and Without Type 1 Diabetes in Sweden From 2010 to 2022.

IF 2.1 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2025-07-15 DOI:10.1111/apa.70230

Alexandra Goldberg, Eva Wiberg-Itzel, Joanna Tingström, Cecilia Ekéus

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引用次数: 0

Abstract

Aim: This register-based study aimed to investigate differences in adverse neonatal outcomes between neonates born to mothers with and without type 1 diabetes in Sweden.

Methods: A nationwide cohort study was conducted using the Swedish Medical Birth Register, including all singleton births from 22 gestational weeks between 2010 and 2022. The neonatal outcomes among neonates of women with and without type 1 diabetes were studied with descriptive statistics and logistic regressions. Adjusted odds ratios (aORs) with 95% confidence intervals are presented.

Results: The study consisted of 1 402 394 neonates, and 0.5% had a mother with type 1 diabetes. Neonates of mothers with type 1 diabetes had increased odds of stillbirth (aOR 2.54; 95% CI 1.98-3.28), congenital malformations (aOR 1.66; 95% CI 1.50-1.84), preterm birth (aOR 3.80; 95% CI 3.41-4.23), large for gestational age (aOR 22.0; 95% CI 20.9-23.1), hypoglycaemia (aOR 45.85; 95% CI 43.60-48.22), and neonatal death (aOR 4.1; 95% CI 3.00-5.83).

Conclusion: Neonates of mothers with type 1 diabetes continue to experience poorer neonatal outcomes, highlighting the need for more research on the causes and how care can be improved for their mothers during pregnancy.

查看原文本刊更多论文

2010年至2022年瑞典1型糖尿病女性和非1型糖尿病女性新生儿结局

目的：这项基于登记的研究旨在调查瑞典1型糖尿病母亲和非1型糖尿病母亲所生新生儿不良结局的差异。方法：使用瑞典医学出生登记处进行了一项全国性队列研究，包括2010年至2022年间所有22孕周的单胎婴儿。采用描述性统计和logistic回归对有和无1型糖尿病妇女的新生儿结局进行研究。校正优势比（aORs）为95%置信区间。结果：本研究共纳入1 402 394名新生儿，其中0.5%的新生儿母亲患有1型糖尿病。1型糖尿病母亲的新生儿死产几率增加(aOR 2.54；95% CI 1.98-3.28)，先天性畸形(aOR 1.66；95% CI 1.50-1.84)，早产(aOR 3.80；95% CI 3.41-4.23)，胎龄较大(aOR 22.0；95% CI 20.9-23.1)，低血糖(aOR 45.85；95% CI 43.60-48.22)和新生儿死亡(aOR 4.1；95% ci 3.00-5.83)。结论：母亲患有1型糖尿病的新生儿的新生儿结局继续较差，强调需要对其原因进行更多的研究，以及如何在怀孕期间改善对母亲的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries