Rinat K Raupov, Evgeny N Suspitsin, Lubov S Sorokina, Ekaterina K Zaikova, Olga V Kalinina, Mikhail M Kostik
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引用次数: 0
Abstract
Aim: To analyze a broad spectrum of cytokine in the serum of patients with JDM.
Background: Juvenile dermatomyositis (JDM) is the most common subtype of idiopathic inflammatory myopathies characterized by muscle and skin involvement. The etiology of JDM is unclear. A variety of cytokines play a role in the pathogenesis of JDM. Interferons, galectin-9, CLCX10, and neopterin are the most promising biomarkers.
Objective: This study describes the associations between clinical symptoms, cytokine, and interferon profiles in children with JDM.
Materials and methods: Ten patients (6 girls and 4 boys) with JDM were included in the study. The clinical symptoms, disease activity (CMAS, CAT), laboratory parameters, and treatment were assessed. Forty-one cytokines levels and IFN-I scores in the serum were measured. The levels of cytokines were compared with a group of healthy controls (n=25).
Results: Significant differences were observed in 21 of 41 analyzed cytokines between JDM patients and healthy controls. Patients with active disease (n=8) have higher levels of fractalkine (p = 0.036), IFNa (p = 0.037), IFNg (p = 0.037), GRO (p = 0.037), IL-10 (p = 0.037), IL-12p40 (p = 0.037), IL-12p70 (p = 0.048), IL-17a (p = 0.048), IL-1RA (p = 0.037), IL-1a (p = 0.037), compared to patients with inactive disease (n=2). A strong positive association was found between aCAT activity and eotaxin (r=0.753, p =0.012), GRO (r=0.735, p =0.015), IP-10 (r=0.805, p =0.005), and MCP-1 (r=0.734, p =0.016). A strong negative correlation association was observed between CMAS and eotaxin (r= -0.714, p =0.020), GRO (r= -0.727, p =0.017), IL-10 (r= -0.786, p =0.007), IP-10 (r= - 0.719, p =0.019), and MCP-1 (r= -0.800, p =0.005). IFN-I scores showed a positive correlation with IFNa (r=0.790, p =0.007), GRO (r=0.736, p =0.015) and IL-1RA (r=0.930, p <0.001).
Conclusion: Among the spectrum of 41 cytokines, GRO, eotaxin, IP-10, and MCP-1 have shown the strongest association with JDM activity.
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