Hala Fathi EmamElkhir Omer, Mohamed Alghazali, Mohamed Y Ibrahim, Nadeen Mohamed Yousif Abdalla, Ashraf Hassan Mohamed Hassan, Eram Asim Seidahmed Yousif, Aseel E B Abdhameed, Yaser Waheeb Slaiman Naser, Nawras Mustafa Elashai Hamad, Malaz A I Abdalla, Mohamed Osman Mohamed Idres, Ali Abdelhaleem Omar Ahmed, Yasir Ahmed Mohammed Elhadi, Sagad O O Mohamed
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引用次数: 0
Abstract
Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide, with increasing evidence linking metabolic dysregulation, such as insulin resistance and chronic inflammation, to its development and progression. A potential useful predictor of CRC risk is the triglyceride-glucose (TyG) index, a marker for insulin resistance that is determined using fasting triglyceride and glucose levels. The purpose of this systematic review was to assess the relationship between the TyG index and CRC and ascertain whether the TyG index is associated with the development and outcomes of CRC.
Methods: A systematic review and meta-analysis was reported in accordance with the PRISMA guidelines. Comprehensive searches of PubMed, Web of Science, Scopus, and World Health Organization Virtual Health Library were conducted in 24th March 2025 to find studies assessing the relationship between the TyG index and CRC. Results of association between TyG index and CRC were summarized and a meta-analysis was done to calculate pooled hazard ratio (HR) with 95% confidence interval (CI).
Results: A total of eight studies were included in the systematic review, of which five met the criteria for inclusion in the quantitative synthesis. The pooled analysis showed that the hazard of developing CRC was significantly greater for those with a higher TyG index (HR = 1.18; 95% CI: 1.12-1.25; P <.001). In addition, meta-analysis indicated that hazard of developing CRC significantly increased for each one-unit increase in the TyG index (HR = 1.28, 95% CI: 1.18 to 1.39, P <.001).
Conclusion: Higher TyG index level is substantially linked to an elevated hazard of developing CRC. Therefore, the TyG index can be a useful tool for CRC risk identification. Standardizing cut-off values and researching clinical applicability in various populations should be the main goals of future research. Due to the limitations posed by the small number of studies, further prospective studies are needed to generate more robust and generalizable evidence.
背景：结直肠癌（CRC）是世界范围内最常见的恶性肿瘤之一，越来越多的证据表明代谢失调，如胰岛素抵抗和慢性炎症，与结直肠癌的发生和发展有关。甘油三酯-葡萄糖（TyG）指数是结直肠癌风险的一个潜在有用的预测指标，它是胰岛素抵抗的标志，通过空腹甘油三酯和葡萄糖水平来确定。本系统综述的目的是评估TyG指数与CRC之间的关系，并确定TyG指数是否与CRC的发展和结局相关。方法：根据PRISMA指南进行系统回顾和荟萃分析。我们于2025年3月24日对PubMed、Web of Science、Scopus和World Health Organization Virtual Health Library进行综合检索，寻找评估TyG指数与CRC关系的研究。总结TyG指数与CRC之间的关联结果，并进行meta分析，以95%可信区间（CI）计算合并风险比（HR）。结果：系统评价共纳入8项研究，其中5项符合定量综合纳入标准。合并分析显示，TyG指数越高，发生结直肠癌的风险越高(HR = 1.18；95% ci: 1.12-1.25；结论：较高的TyG指数水平与发生结直肠癌的风险升高密切相关。因此，TyG指数可以作为CRC风险识别的有用工具。标准化临界值和研究在不同人群中的临床适用性应该是未来研究的主要目标。由于研究数量较少，因此需要进一步的前瞻性研究来产生更可靠和可推广的证据。
期刊介绍：
World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics.
Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.
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