Haplo-hematopoietic stem cell transplantation and immunoradiotherapy for severe aplastic anemia complicated with nasopharyngeal carcinoma: A case report.

IF 1.7 4区 生物学 Q3 BIOLOGY
Open Life Sciences Pub Date : 2025-07-11 eCollection Date: 2025-01-01 DOI:10.1515/biol-2025-1134
Yanting Gao, Yun Zhang, Hong Wang, Jingjing Xiang, Xiangping Wu, Qinghong Yu
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引用次数: 0

Abstract

Severe aplastic anemia (SAA) and nasopharyngeal carcinoma (NPC) are two different diseases and are life-threatening if left untreated. The co-occurrence of SAA and NPC is rare and presents a complex therapeutic paradox. This study reports a unique case of a patient diagnosed with both SAA and NPC. The patient initially underwent haploidentical hematopoietic stem cell transplantation (HSCT) to achieve rapid hematologic recovery, followed by nimotuzumab + radiotherapy for carcinoma treatment. This case suggests that sequential haploidentical HSCT and radiotherapy may represent a promising therapeutic strategy for patients with coexisting SAA and NPC.

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单倍造血干细胞移植联合免疫放疗治疗重度再生障碍性贫血合并鼻咽癌1例。
严重再生障碍性贫血(SAA)和鼻咽癌(NPC)是两种不同的疾病,如果不及时治疗,将危及生命。SAA和NPC同时发生是罕见的,并且呈现出一个复杂的治疗悖论。本研究报告了一个诊断为SAA和NPC的独特病例。患者最初接受单倍体造血干细胞移植(HSCT)以实现血液系统快速恢复,随后接受尼莫单抗+放疗治疗癌症。该病例提示,序贯单倍体HSCT和放疗可能是同时存在SAA和NPC患者的一种有希望的治疗策略。
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来源期刊
CiteScore
2.50
自引率
4.50%
发文量
131
审稿时长
43 weeks
期刊介绍: Open Life Sciences (previously Central European Journal of Biology) is a fast growing peer-reviewed journal, devoted to scholarly research in all areas of life sciences, such as molecular biology, plant science, biotechnology, cell biology, biochemistry, biophysics, microbiology and virology, ecology, differentiation and development, genetics and many others. Open Life Sciences assures top quality of published data through critical peer review and editorial involvement throughout the whole publication process. Thanks to the Open Access model of publishing, it also offers unrestricted access to published articles for all users.
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