Effect of Ginkgo biloba extracts in the prevention of posterior capsule opacification after cataract surgery: A randomized clinical trial.

Q3 Medicine

Oman Journal of Ophthalmology Pub Date : 2025-06-24 eCollection Date: 2025-05-01 DOI:10.4103/ojo.ojo_311_21

Amir Ahmadzadeh Amiri, Reza Jafari, Ali Ahmadzadeh Amiri, Hossein Asgari Rad, Fatemeh Daneshvar, Jamshid Yazdani Charati, Ahmad Ahmadzadeh Amiri

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引用次数: 0

Abstract

Purpose: This study aims to explore the effect of Ginkgo biloba extracts (GbE) on the prevention of posterior capsule opacification (PCO).

Study design: This study was a double-blinded, placebo-controlled, single-center randomized clinical trial.

Methods: Patients with senile cataracts randomly received GbE supplement capsules at a dose of 200 mg (n = 74) or an identical placebo (n = 70) daily for 6 months after cataract surgery. Patients' follow-ups were scheduled for up to 3 years after cataract surgery. PCO formation (Pearl/Fibrotic) was graded using slit-lamp examinations. The necessity of a Neodymium-doped yttrium aluminum garnet (Nd: YAG) laser capsulotomy was evaluated by patients' complaints of reduced visual acuity imputable to PCO.

Results: A total of 144 patients with a mean age of 64.92 ± 7.77 years were studied. The mean Log MAR visual acuity in the placebo group started to decrease at 12 months (P = 0.003) and remained significantly lower than the GbE group throughout 36 months (P = 0.005). At 1-year postsurgery, a significant difference between the two groups of GbE and Placebo was observed regarding pearl PCO score, but obvious fibrotic PCO score differences occurred 3 years after surgery. The Nd: YAG capsulotomy was performed in six eyes (6.1%) for the GbE group and 18 eyes (20.4%) for the placebo group (P = 0.004) 3 years after the cataract surgery.

Conclusion: Six months of supplementation with GbE was well tolerated and may provide some marginal prevention in the PCO formation. Besides the effect of the GbE in the inhibition of PCO, we also observed a noticeable reduction in the need for Nd: YAG laser capsulotomy.

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银杏叶提取物预防白内障术后后囊膜混浊的随机临床试验

目的：探讨银杏叶提取物（GbE）对后囊膜混浊（PCO）的预防作用。研究设计：本研究为双盲、安慰剂对照、单中心随机临床试验。方法：老年性白内障患者在白内障手术后6个月，每天随机给予200 mg GbE补充胶囊（n = 74）或相同的安慰剂（n = 70）。白内障手术后患者随访时间长达3年。采用裂隙灯检查对PCO形成（珍珠/纤维化）进行分级。通过患者对PCO导致的视力下降的主诉，评价了采用掺钕钇铝石榴石（Nd: YAG）激光包膜切开术的必要性。结果：共纳入144例患者，平均年龄64.92±7.77岁。安慰剂组的平均Log MAR视力在12个月时开始下降（P = 0.003），并且在整个36个月期间仍显著低于GbE组（P = 0.005）。术后1年GbE组与安慰剂组珍珠PCO评分差异有统计学意义，术后3年纤维化PCO评分差异明显。术后3年，GbE组6眼（6.1%）行Nd: YAG囊切除术，安慰剂组18眼（20.4%）行Nd: YAG囊切除术（P = 0.004）。结论：6个月补充GbE耐受性良好，可能对PCO的形成有一定的预防作用。除了GbE在抑制PCO方面的作用外，我们还观察到Nd: YAG激光包膜切开术的需求显著减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oman Journal of Ophthalmology Medicine-Ophthalmology

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

50 weeks

期刊介绍： To provide a platform for scientific expression of the Oman Ophthalmic Society and the international Ophthalmic community and to provide opportunities for free exchange of ideas and information. To serve as a valuable resource for ophthalmologists, eye-care providers including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science.