11α-hydroxydysobinin: a new limonoid from Chisocheton macrophyllus seeds (Meliaceae).

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI:10.1080/10286020.2025.2525332

Lulu Wilden Azzahra, Wahyu Safriansyah, Muhammad Badrul Huda, Desi Harneti, Tri Mayanti, Kindi Farabi, Rani Maharani, Unang Supratman

引用次数: 0

Abstract

A new limonoid compound 11α-hydroxydisobinin (1), along with a known limonoid compound (2), was isolated from ethyl acetate extract of Chisocheton macrophyllus (Meliaceae) seeds. The structure and stereochemical configuration of compound 1 was characterized by HR-ESI-MS, UV, IR, NMR, and ECD analysis through quantum chemical calculations (TD-DFT analysis and DP4+ NMR). Both limonoids were tested for their cytotoxic activities against MCF-7 breast cancer cells with IC₅₀ values of 112.5 and 51.7 µM.

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11α-hydroxydysobinin：一种新发现的类柠檬素。

从芫荽种子的乙酸乙酯萃取物中分离得到一个新的类柠檬素化合物11α-羟基二比素(1)和一个已知的类柠檬素化合物(2)。通过量子化学计算（TD-DFT分析和DP4+ NMR）对化合物1的结构和立体构型进行了HR-ESI-MS、UV、IR、NMR和ECD分析。两种柠檬素对MCF-7乳腺癌细胞的IC50分别为112.5µM和51.7µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.