{"title":"Global Research Trends and Collaborative Networks in Cellular Therapy for Crohn's Disease: A Systematic Review and Bibliographic Analysis.","authors":"Tunç Akkoç","doi":"10.1007/5584_2025_866","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal system characterized by periods of remission and relapse. This study aims to provide a comprehensive bibliometric analysis of CD cellular therapy research over the past 30 years.</p><p><strong>Methods: </strong>Data was accessed and downloaded from the Web of Science (WoS) database on June 18, 2024, using specific search terms related to CDs and cellular therapy, covering the years 1992-2023. The search was limited to articles and review articles in English. The data was analyzed using R Studio Bibliometric to evaluate metrics such as global and local citations, source journals, and fractionalized author contributions.</p><p><strong>Results: </strong>The analysis identified 559 documents from 258 sources, with an annual growth rate of 13.45%. The dataset included 309 original research articles and 234 review articles, contributed by 3,181 authors. A significant publication increase was observed from 2009 onward, peaking in 2019. The mean total citations per year showed notable fluctuations, with peaks in 2000 and 2007. The Cleveland Clinic Foundation, Sun Yat-Sen University, and Mayo Clinic were prominent institutions contributing to the research. The USA led publication output and citations, followed by Spain, China, Italy, and Canada.</p><p><strong>Conclusion: </strong>The management of CD has evolved significantly with advancements in cellular therapy and therapeutic strategies. Despite the growth in research and available treatment options, there remains a lack of broad consensus in clinical practice. This bibliometric analysis highlights the progress in cellular therapy for CD.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/5584_2025_866","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal system characterized by periods of remission and relapse. This study aims to provide a comprehensive bibliometric analysis of CD cellular therapy research over the past 30 years.
Methods: Data was accessed and downloaded from the Web of Science (WoS) database on June 18, 2024, using specific search terms related to CDs and cellular therapy, covering the years 1992-2023. The search was limited to articles and review articles in English. The data was analyzed using R Studio Bibliometric to evaluate metrics such as global and local citations, source journals, and fractionalized author contributions.
Results: The analysis identified 559 documents from 258 sources, with an annual growth rate of 13.45%. The dataset included 309 original research articles and 234 review articles, contributed by 3,181 authors. A significant publication increase was observed from 2009 onward, peaking in 2019. The mean total citations per year showed notable fluctuations, with peaks in 2000 and 2007. The Cleveland Clinic Foundation, Sun Yat-Sen University, and Mayo Clinic were prominent institutions contributing to the research. The USA led publication output and citations, followed by Spain, China, Italy, and Canada.
Conclusion: The management of CD has evolved significantly with advancements in cellular therapy and therapeutic strategies. Despite the growth in research and available treatment options, there remains a lack of broad consensus in clinical practice. This bibliometric analysis highlights the progress in cellular therapy for CD.
简介：克罗恩病（CD）是一种胃肠道系统的慢性炎症性疾病，以缓解期和复发期为特征。本研究旨在对过去30年的CD细胞治疗研究进行全面的文献计量学分析。方法：于2024年6月18日，使用cd和细胞治疗相关的特定检索词，从Web of Science （WoS）数据库中获取并下载数据，检索时间为1992-2023年。检索仅限于英文文章和综述文章。使用R Studio Bibliometric对数据进行分析，以评估诸如全球和本地引用，来源期刊和作者贡献分数等指标。结果：共鉴定文献559篇，来源258篇，年增长率为13.45%。该数据集包括309篇原创研究文章和234篇综述文章，由3181位作者贡献。从2009年开始，论文发表量显著增加，并在2019年达到顶峰。年平均总引用量波动较大，峰值出现在2000年和2007年。克利夫兰诊所基金会、中山大学和梅奥诊所是为这项研究做出贡献的著名机构。美国的论文发表量和引用量居首位，其次是西班牙、中国、意大利和加拿大。结论：随着细胞疗法和治疗策略的进步，乳糜泻的治疗发生了重大变化。尽管研究和可用的治疗方案有所增加，但在临床实践中仍然缺乏广泛的共识。这一文献计量学分析强调了细胞治疗乳糜泻的进展。
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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