Functions of the KCNE Gene Family in Ion Channels.

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Genetics Pub Date : 2025-07-16 DOI:10.1007/s10528-025-11202-3

Junshen Xiao, Xu Cheng, Dou Huang, Shichao Wei, Zhaoyang Hu

引用次数: 0

Abstract

The KCNE gene family is crucial for physiological and pathological processes in the body and encodes small transmembrane proteins that function as auxiliary subunits to regulate voltage-gated potassium channels (K_v channels). This family includes five members, KCNE1, KCNE2, KCNE3, KCNE4, and KCNE5, whose encoded proteins are referred to as MinK and MinK-related peptides (MiRPs), which influence the properties and localization of K_v. When KCNE is coexpressed with Kv, it can alter the conductance, gating kinetics, and pharmacology of the channel. Therefore, these genes are particularly important for action potentials in excitable cells, and mutations in these genes can lead to significant diseases. In this paper, we review the functional roles of KCNE genes and their effects on Kv α subunits to further understand the regulatory effects of KCNE in modulating ion channels.

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KCNE基因家族在离子通道中的功能。

KCNE基因家族对身体的生理和病理过程至关重要，并编码小的跨膜蛋白，作为辅助亚基调节电压门控钾通道（Kv通道）。该家族包括KCNE1、KCNE2、KCNE3、KCNE4和KCNE5 5个成员，其编码的蛋白被称为MinK和MinK相关肽（MiRPs），影响Kv的性质和定位。当KCNE与Kv共表达时，它可以改变通道的电导、门控动力学和药理学。因此，这些基因对可兴奋细胞的动作电位特别重要，这些基因的突变可导致重大疾病。本文就KCNE基因的功能作用及其对Kv α亚基的影响进行综述，以期进一步了解KCNE在离子通道调节中的调控作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical Genetics 生物-生化与分子生物学

CiteScore

3.90

自引率

0.00%

发文量

133

审稿时长

4.8 months

期刊介绍： Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses. Although studies focusing on particular regions and target organisms are welcome, it is not the journal’s goal to publish essentially descriptive studies that provide results with narrow applicability, or are based on very small samples or pseudoreplication. Rather, Biochemical Genetics welcomes review articles that go beyond summarizing previous publications and create added value through the systematic analysis and critique of the current state of knowledge or by conducting meta-analyses. Methodological articles are also within the scope of Biological Genetics, particularly when new laboratory techniques or computational approaches are fully described and thoroughly compared with the existing benchmark methods. Biochemical Genetics welcomes articles on the following topics: Genomics; Proteomics; Population genetics; Phylogenetics; Metagenomics; Microbial genetics; Genetics and evolution of wild and cultivated plants; Animal genetics and evolution; Human genetics and evolution; Genetic disorders; Genetic markers of diseases; Gene technology and therapy; Experimental and analytical methods; Statistical and computational methods.