Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani
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引用次数: 0
Abstract
Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads. Among them, phytocompounds have been amply exploited in the search for new autophagy modulators to tackle diseases like cancer and degenerative disorders, while their use as potential antiviral agents has been explored to a limited extent. The modulation of autophagy in viral infections may play a dual and contraposing role. Depending on the replication mechanism of the virus, it may serve as an adjuvant in the innate immune response of the host, or it may be hijacked by viruses, favoring their replication. This review is intended to present an overview of antiviral natural compounds and extracts capable of modulating autophagy, and it seeks to provide a solid foundation for researchers to further investigate the mechanisms of autophagy modulation during viral infections and to identify diverse molecular entities for antiviral drug discovery.
期刊介绍:
Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field.
Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.