A Focus on Natural Autophagy Modulators as Potential Host-Directed Weapons Against Emerging and Re-Emerging Viruses.

IF 11.6 1区 医学 Q1 CHEMISTRY, MEDICINAL
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani
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引用次数: 0

Abstract

Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads. Among them, phytocompounds have been amply exploited in the search for new autophagy modulators to tackle diseases like cancer and degenerative disorders, while their use as potential antiviral agents has been explored to a limited extent. The modulation of autophagy in viral infections may play a dual and contraposing role. Depending on the replication mechanism of the virus, it may serve as an adjuvant in the innate immune response of the host, or it may be hijacked by viruses, favoring their replication. This review is intended to present an overview of antiviral natural compounds and extracts capable of modulating autophagy, and it seeks to provide a solid foundation for researchers to further investigate the mechanisms of autophagy modulation during viral infections and to identify diverse molecular entities for antiviral drug discovery.

自然自噬调节剂作为潜在的宿主定向武器对抗新出现和再出现的病毒。
自噬是一种高度保守的细胞内过程,参与维持体内平衡和降解受损的细胞器和外部病原体。自然界提供了复杂多样的支架和化学实体储存库,它们可能在寻找新的治疗线索方面发挥关键作用。其中,植物化合物在寻找新的自噬调节剂以治疗癌症和退行性疾病等疾病方面得到了充分的利用,而它们作为潜在的抗病毒药物的使用却得到了有限的探索。病毒感染中自噬的调节可能起着双重和相反的作用。根据病毒的复制机制,它可能作为宿主先天免疫反应的辅助剂,也可能被病毒劫持,有利于它们的复制。本文旨在综述能够调节自噬的抗病毒天然化合物和提取物,为研究人员进一步研究病毒感染过程中自噬调节的机制和确定抗病毒药物的不同分子实体提供坚实的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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