Functionally diverse human insular architecture with memory-related hippocampal interactions

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-07-16 DOI:10.1038/s41593-025-02035-9

引用次数: 0

Abstract

Direct and simultaneous recordings across the human brain during a memory encoding task involving emotionally valenced words revealed tightly clustered neuronal sites within the insular cortex with distinct roles — some tracked valence, whereas others predicted memory. Only memory-related insular sites, when electrically stimulated, sparked strong hippocampal responses, uncovering a specialized insula–hippocampus axis for successful memory encoding.

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功能多样的人类岛结构与记忆相关的海马体相互作用

在涉及情感价词的记忆编码任务中，人类大脑的直接和同步记录显示，岛叶皮层内紧密聚集的神经元位点具有不同的作用——一些追踪价词，而另一些预测记忆。当电刺激时，只有与记忆相关的岛状体部位才会引发强烈的海马体反应，从而揭示了成功编码记忆的特殊岛状体-海马体轴。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.