Near-infrared photoimmunotherapy for recurrent cancer at the base of the tongue

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-12 DOI:10.1016/j.pdpdt.2025.104719

Takuma Makino , Asami Nishikori , Yasuharu Sato , Yuto Naoi , Junya Matsumoto , Shohei Fujimoto , Mizuo Ando

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引用次数: 0

Abstract

Near-infrared photoimmunotherapy (NIR-PIT) is a novel therapeutic approach that targets epidermal growth factor receptor (EGFR). In NIR-PIT, administration of cetuximab sarotalocan sodium is followed by laser irradiation of the affected area, which theoretically should induce tumor cell death. However, residual tumors are occasionally observed. This study investigated factors that influence the therapeutic efficacy of NIR-PIT in cases of recurrence of cancer at the base of the tongue. Six patients undergoing 11 treatment cycles were analyzed, focusing on the puncture interval of cylindrical diffusers and the expression of EGFR in tumors. The results demonstrated that a puncture interval of ≤12 mm significantly enhanced therapeutic efficacy, with one case achieving complete response. EGFR expression was positive in all cases and expression score showed no significant change between before and after treatment. These findings suggest that puncture interval plays a critical role in therapeutic outcomes, whereas EGFR expression may not directly influence treatment efficacy.

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近红外光免疫疗法治疗舌底癌复发。

近红外光免疫疗法（NIR-PIT）是一种针对表皮生长因子受体（EGFR）的新型治疗方法。在NIR-PIT中，给药西妥昔单抗沙罗他罗坎钠后，激光照射患处，理论上应该会诱导肿瘤细胞死亡。然而，偶尔也会观察到残留的肿瘤。本研究探讨影响舌底癌复发患者NIR-PIT治疗效果的因素。我们分析了6例患者11个治疗周期，重点分析了柱状扩散器穿刺间隔和肿瘤中EGFR的表达。结果表明，穿刺间隔≤12 mm可显著提高治疗效果，其中1例达到完全缓解。所有病例EGFR表达均为阳性，治疗前后表达评分无明显变化。这些发现表明，穿刺间隔在治疗结果中起关键作用，而EGFR表达可能不会直接影响治疗效果。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.