Efficacy of non-invasive photobiomodulation for congenital color vision deficiency: A randomized controlled trial

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-12 DOI:10.1016/j.pdpdt.2025.104721

Nandi Bao , Chunyi Jia , Liang Jia

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引用次数: 0

Abstract

Background

Congenital color vision deficiency (CVD) is a prevalent ophthalmic condition for which effective therapeutic interventions remain limited. This study evaluated the efficacy of photobiomodulation (PBM) therapy in individuals with congenital CVD.

Methods

A randomized, single-blind, controlled clinical trial was conducted involving 80 participants diagnosed with red-green CVD. Participants were randomly assigned to either a PBM treatment group or a control group. Color vision performance was assessed at baseline, and after 1, 2, and 4 weeks of intervention. Statistical analyses were conducted using the Kruskal-Wallis test with Dunn’s post hoc test for multiple comparisons.

Results

Color vision recognition ability demonstrated a statistically significant improvement in the PBM treatment group compared to the control group across various parameters (p < 0.05).

Conclusion

Non-invasive PBM therapy significantly enhances color vision in individuals with congenital CVD, with particularly notable improvements observed in those with green CVD.

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无创光生物调节治疗先天性色觉缺陷的疗效：一项随机对照试验。

背景：先天性色觉缺陷（CVD）是一种常见的眼科疾病，有效的治疗措施仍然有限。本研究评估了光生物调节（PBM）治疗先天性心血管疾病的疗效。方法：随机、单盲、对照临床试验，纳入80例诊断为红绿心血管疾病的患者。参与者被随机分配到PBM治疗组或对照组。在基线、干预1周、2周和4周后评估色觉表现。统计分析采用Kruskal-Wallis检验和Dunn事后检验进行多重比较。结果：与对照组相比，PBM治疗组色觉识别能力在各参数上均有显著改善（p < 0.05）。结论：无创PBM治疗可显著提高先天性CVD患者的色觉，尤其是绿色CVD患者的色觉改善尤为显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.