Development and Content of Core Outcome Sets in Neonatology-A Scoping Review.

IF 2.4 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2025-07-15 DOI:10.1111/apa.70232

Ilari Kuitunen, Panu Kiviranta, Marjut Haapanen, Peter G Davis

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引用次数: 0

Abstract

Aim: To identify subgroups of neonates for whom core outcome sets (COS) have been developed, the outcomes that were included and the methods used in their formulation.

Methods: We performed a scoping review and searched databases in April 2025 for published COS. We included COS that reported neonatal outcomes, even when the original interventions targeted pregnant individuals. Methods of COS development and the included outcomes were extracted for descriptive analysis.

Results: A total of 363 abstracts were screened and 34 COS studies included for analysis. The most used methods were modified Delphi and Delphi consensus methods, consisting of a median of three rounds and a consensus meeting. Overall, a total of 62 distinct neonatal outcomes were proposed. The five most commonly included outcomes were neonatal mortality, preterm birth, birth weight, need for neonatal intensive care unit admission and neurodevelopment.

Conclusion: We found that the neonatal core outcome sets had clear heterogeneity in their selected outcomes. Future primary studies and evidence reviews should aim to focus on including important outcomes, when possible, to improve consistency in reporting.

Protocol registration: Protocol was registered to open science framework and is available from https://osf.io/yngbd/.

查看原文本刊更多论文

新生儿科学核心结局集的发展和内容——范围综述。

目的：确定已开发的核心结局集（COS）的新生儿亚组，包括的结果及其制定中使用的方法。方法：我们于2025年4月对已发表的COS进行了范围综述和数据库检索。我们纳入了报告新生儿结局的COS，即使最初的干预是针对孕妇的。提取COS发展方法及纳入结果进行描述性分析。结果：共筛选363篇摘要，纳入34篇COS研究进行分析。最常用的方法是修正德尔菲法和德尔菲共识法，由三轮的中位数和一次共识会议组成。总的来说，总共提出了62种不同的新生儿结局。最常见的五个结果是新生儿死亡率、早产、出生体重、新生儿重症监护病房住院需求和神经发育。结论：我们发现新生儿核心结局组在其选择的结局上有明显的异质性。未来的初步研究和证据评价应侧重于在可能的情况下纳入重要结果，以提高报告的一致性。协议注册：协议已注册到开放科学框架，可从https://osf.io/yngbd/获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries