Assessing grey matter structural alterations in systemic lupus erythematosus using synthetic MRI.

IF 3.7 2区医学 Q1 RHEUMATOLOGY

Lupus Science & Medicine Pub Date : 2025-07-13 DOI:10.1136/lupus-2025-001505

Kemei Deng, Chengli Wu, Yuhong Qin, Wei Cui, Jing Wen, Muliang Jiang, Liling Long, Bihong T Chen

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引用次数: 0

Abstract

Objectives: To assess brain grey matter alterations in patients with SLE and their correlation with neuropsychological testing using synthetic MRI (SyMRI).

Methods: This prospective study enrolled patients with SLE and age, gender and education-matched healthy controls (HC). Study assessments included brain MRI using SyMRI and neuropsychological tests: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Digit Span Test, Self-Rating Anxiety Scale and Self-Rating Depression Scale (SDS). SyMRI post-processing and Automated Anatomical Labeling were used for grey matter mapping. Correlation analysis was performed to assess the relationship between brain grey matter structural alterations and neuropsychological testing.

Results: 77 patients with SLE (57 non-neuropsychiatric SLE (non-NPSLE), 20 NPSLE) and 29 HC participants were enrolled. Patients with SLE showed reduced grey matter volume compared with HC (p<0.05). The NPSLE group exhibited more extensive increases in longitudinal (T1) and transverse (T2) relaxation times in grey matter than the non-NPSLE group (p<0.001). Proton density values were lower in patients with SLE (p<0.001). Lower brain parenchymal volume correlated with higher SLE Disease Activity Index (p<0.05). Lower MMSE/MoCA scores correlated with increased T1/T2 in the left medial cingulate and paracingulate gyri (p<0.05). Higher SDS scores correlated with increased T1/T2 in the left calcarine fissure and surrounding cortex (p<0.05). These changes were also linked to disease markers (C3, C4, immunoglobulin M, erythrocyte sedimentation rate) (p<0.05).

Conclusions: Grey matter alterations in patients with SLE correlate with cognitive impairment, depression and disease activity.

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应用合成MRI评估系统性红斑狼疮灰质结构改变。

目的：利用合成MRI （SyMRI）评估SLE患者脑灰质改变及其与神经心理测试的相关性。方法：本前瞻性研究纳入SLE患者和年龄、性别和教育程度相匹配的健康对照组（HC）。研究评估包括使用SyMRI的脑MRI和神经心理测试：迷你精神状态检查（MMSE）、蒙特利尔认知评估（MoCA）、数字广度测试、焦虑自评量表和抑郁自评量表（SDS）。使用SyMRI后处理和自动解剖标记进行灰质制图。通过相关分析评估脑灰质结构改变与神经心理测试之间的关系。结果：纳入77例SLE患者（57例非神经精神性SLE (non-NPSLE)， 20例NPSLE）和29例HC参与者。与HC相比，SLE患者的灰质体积减少(结论：SLE患者的灰质改变与认知障碍、抑郁和疾病活动相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lupus Science & Medicine RHEUMATOLOGY-

CiteScore

5.30

自引率

7.70%

发文量

审稿时长

15 weeks

期刊介绍： Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.