S1PR1, an endothelial-immune influencer.

IF 12.6 1区医学 Q1 IMMUNOLOGY

Journal of Experimental Medicine Pub Date : 2025-09-01 Epub Date: 2025-07-15 DOI:10.1084/jem.20251056

Samantha Mahfoud, Timothy P Padera

引用次数: 0

Abstract

Lymphatic dysfunction has been associated with tertiary lymphoid structure (TLS) formation in the mesentery. However, our understanding of TLS formation is mainly focused on inflammatory signaling. Here, Geng et al. (https://doi.org/10.1084/jem.20241799) show that lymphatic endothelial cell (LEC) S1P/S1PR1 signaling plays a role in mesenteric TLS formation in the absence of subclinical inflammation and, importantly, is a key regulator of lymphatic valve development.

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S1PR1，内皮免疫影响因子。

淋巴功能障碍与系膜三级淋巴样结构（TLS）的形成有关。然而，我们对TLS形成的理解主要集中在炎症信号上。耿等人（https://doi.org/10.1084/jem.20241799）发现，在没有亚临床炎症的情况下，淋巴内皮细胞（LEC） S1P/S1PR1信号在肠系膜TLS形成中发挥作用，重要的是，它是淋巴瓣膜发育的关键调节因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Experimental Medicine 医学-免疫学

CiteScore

26.60

自引率

1.30%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field. Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions. Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.