Cytotoxic limonoids from the twigs of Chisocheton paniculatus.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI:10.1080/10286020.2025.2525316

Peng Yu, Mu-Yi Yang, Xiong-Wei Hu, Jia Liu

引用次数: 0

Abstract

A chemical study on 80% methanol extract of the twigs of Chisocheton paniculatus led to the isolation of two novel limonoids, paniculatusines A and B (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated limonoids were tested in vitro for cytotoxic activities against 5 hepatocellular carcinoma cell lines (SMMC-7721, Bel-7402, MHCC97, HepG2, and Hep3B). Consequently, limonoid 1 exhibited some cytotoxic activities against all the tested tumor cell lines with IC₅₀ values less than 20 μM.

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细枝小枝的细胞毒性类柠檬素。

化学研究80%甲醇提取的树枝Chisocheton paniculatus隔离了两个新颖的柠檬苦素类似物,paniculatusines A和B(1和2)。新化合物的结构通过一维、二维（HMQC）和HMBC核磁共振波谱以及高分辨率质谱等光谱方法进行了鉴定。体外对5种肝癌细胞系（SMMC-7721、Bel-7402、MHCC97、HepG2和Hep3B）的细胞毒活性进行了检测。结果表明，类柠檬素1对所有肿瘤细胞系均表现出一定的细胞毒活性，IC50值小于20 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.