The effect of lipoprotein (a) elevation on coronary flow reserve.

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Expert Review of Cardiovascular Therapy Pub Date : 2025-07-17 DOI:10.1080/14779072.2025.2534707

Furkan Bolen, Adem Atici, Omer Faruk Baycan, Yusuf Yilmaz, İshak Yilmaz, Ayse Parali, Merve Kapcik, Oguz Konal, Nermin Ismayilzade, Fatma Betul Ozcan, Mustafa Caliskan

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引用次数: 0

Abstract

Background: Lipoprotein (Lp)(a) is a genetically inherited lipoprotein implicated in the progression of cardiovascular diseases and atherosclerosis. This study aims to examine whether elevated Lp(a) levels contribute to the development of subclinical atherosclerosis, compared to individuals with normal Lp(a) levels, using parameters such as coronary flow reserve (CFR).

Research design and methods: The study population included 25 patients with elevated Lp(a) levels and 30 subjects with normal Lp(a) levels, recruited prospectively. Conventional echocardiographic measurements were performed according to established guidelines. Main outcome measures included the comparison of CFR values between the groups.

Results: The CFR was found to be significantly decreased in the group with elevated Lp(a) levels compared to the control group (2.0 ± 0.5 vs. 2.5 ± 0.6, p < 0.001). Additionally, a negative and statistically significant correlation was observed between Lp(a) levels and CFR, indicating that higher Lp(a) levels are associated with lower CFR values (r: -0.657, p < 0.001).

Conclusions: Our study demonstrates that elevated Lp(a) levels are significantly associated with subclinical atherosclerosis and impaired coronary vasomotor function. These findings suggest that lowering Lp(a) levels could effectively reduce the risk of atherosclerotic disease by targeting its role in atherosclerosis pathogenesis.

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lıpoproteın (a) elevatıon对冠状动脉血流储备的影响。

背景：脂蛋白（Lp）(a)是一种遗传性脂蛋白，与心血管疾病和动脉粥样硬化的进展有关。本研究旨在通过冠状动脉血流储备（CFR）等参数，研究与Lp(a)水平正常的个体相比，Lp(a)水平升高是否有助于亚临床动脉粥样硬化的发展。研究设计和方法：前瞻性招募25例Lp(a)水平升高的患者和30例Lp(a)水平正常的患者。常规超声心动图测量是根据既定指南进行的。主要观察指标包括两组间CFR值的比较。结果：与对照组相比，Lp(a)水平升高组的CFR显著降低（2.0±0.5 vs. 2.5±0.6,p p）。结论：我们的研究表明，Lp(a)水平升高与亚临床动脉粥样硬化和冠状动脉血管舒张功能受损显著相关。这些发现表明，降低Lp(a)水平可以通过靶向其在动脉粥样硬化发病机制中的作用，有效降低动脉粥样硬化疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Cardiovascular Therapy CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.