Shaokai Tang, Jianhua Zhang, Jiawei Chen, Zeng Zhou, Qinqin Lin
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引用次数: 0
Abstract
Neurodegenerative diseases represent a major global cause of mortality and disability. These disorders are characterized by complex pathogenesis and currently lack effective therapeutic strategies. Iron, a vital trace element for normal brain function, has been implicated in the pathogenesis of neurodegenerative diseases via the ferroptosis pathway. Emerging evidence indicates that exercise can suppress ferroptosis directly or indirectly by regulating iron metabolism, oxidative stress, and exerkine expression, thereby conferring neuroprotection. This review summarizes current insights into the role of ferroptosis in neurodegenerative diseases and explores the mechanisms by which exercise modulates the ferroptosis pathway, offering a scientific rationale for exercise-based interventions in brain health.
期刊介绍：
Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board.
The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology.
With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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