Evaluation of Pan-immune Inflammation Value and Systemic Immune Inflammation Index in Different Mood Episodes of Bipolar Disorder.

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-03-07 DOI:10.9758/cpn.24.1260

Medine Gıynaş Ayhan, Hazel Demiröz Öztürk, İkbal İnanlı

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引用次数: 0

Abstract

Objective: Pan-immune inflammation value (PIV) and systemic immune-inflammation index (SII) have recently been investigated as new inflammatory markers. The aim of this study was to investigate and compare the PIV and SII in different mood episodes in bipolar disorder (BD) and healthy controls (HC).

Methods: In this study, white blood cells, neutrophil, monocyte, lymphocyte, and platelet counts of 339 BD patients (138 manic, 100 depressive, and 101 euthymic patients) along with 117 HC were evaluated. The PIV and the SII were calculated using these parameters and compared between the groups.

Results: PIV (p < 0.001) and SII (p = 0.002) were significantly higher in the manic group than in the HC. A comparison of the HC with the depressed and euthymic groups indicated no significant difference in PIV (p = 0.086, p = 0.139, respectively) and SII (p = 0.555, p = 0.244, respectively), while neutrophil (p = 0.043, p = 0.042, respectively) and monocyte (p = 0.010, p = 0.023, respectively) counts were significantly higher. Compared to the depressed and euthymic patients, the manic patients had significantly higher PIV (p <0.001, p <0.001, respectively) and SII (p = 0.019, p = 0.034, respectively). PIV could to be predictive in distinguishing manic episode patients from the other groups.

Conclusion: Our findings highlight the role of the low-grade systemic inflammation in the pathophysiology of BD, particularly during the manic episode, and suggest that PIV could serve as an inflammation marker to distinguish the manic episode of BD from other phases.

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双相情感障碍不同情绪发作期泛免疫炎症值及全身免疫炎症指数的评价。

目的：研究泛免疫炎症值（PIV）和全身免疫炎症指数（SII）作为新的炎症指标。本研究的目的是调查和比较双相情感障碍（BD）和健康对照（HC）不同情绪发作的PIV和SII。方法：对339例躁狂症患者（138例躁狂症患者，100例抑郁症患者，101例胸腺炎患者）和117例HC患者的白细胞、中性粒细胞、单核细胞、淋巴细胞和血小板计数进行了检测。使用这些参数计算PIV和SII，并在组间进行比较。结果：躁狂组PIV （p < 0.001）和SII （p = 0.002）明显高于HC组。HC组与抑郁组、正常组比较，PIV （p = 0.086, p = 0.139）、SII （p = 0.555, p = 0.244）差异无统计学意义，而中性粒细胞（p = 0.043, p = 0.042）、单核细胞（p = 0.010, p = 0.023）计数明显升高。躁狂患者的PIV显著高于抑郁和心境正常患者（p = 0.019, p = 0.034）。PIV可作为区分躁狂发作患者与其他组的预测指标。结论：我们的研究结果强调了低级别全身性炎症在双相障碍病理生理中的作用，特别是在躁狂发作期间，并提示PIV可以作为区分双相障碍躁狂发作与其他阶段的炎症标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.