Association between life's essential 8 score and the risk of abdominal aortic aneurysm: a prospective cohort study from UK Biobank data.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2025-07-14 DOI:10.1186/s12889-025-22758-5

Sixu Chen, Zegui Huang, Dachuan Guo, Chang Guan, Zhiteng Chen, Tingfeng Chen, Haifeng Zhang, Yangxin Chen, Jingfeng Wang

{"title":"Association between life's essential 8 score and the risk of abdominal aortic aneurysm: a prospective cohort study from UK Biobank data.","authors":"Sixu Chen, Zegui Huang, Dachuan Guo, Chang Guan, Zhiteng Chen, Tingfeng Chen, Haifeng Zhang, Yangxin Chen, Jingfeng Wang","doi":"10.1186/s12889-025-22758-5","DOIUrl":null,"url":null,"abstract":"Background: The healthy lifestyle factors have been closely associated with the risk of abdominal aortic aneurysm. The American Heart Association (AHA) recently released a checklist of health factors known as Life's Essential 8 (LE8) to optimize cardiovascular health. The aim of this study was to test the hypothesis that greater adherence to the LE8 score was associated with a decreased risk of new-onset abdominal aortic aneurysm (AAA).Methods: This study included 279,251 UK Biobank participants without a history of AAA. LE8 score was calculated using 8 metrics according to the AHA's definition, and the study population was divided into four groups based on LE8 quartile. The Cox proportional hazard model was used to assess the association between LE8 score and risk of AAA.Results: During a median follow-up of 12.77 years, 1042 cases of incident AAA were identified. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of AAA was 0.52 (0.43, 0.64) for the Q2 group, 0.39 (0.32, 0.49) for the Q3 group, and 0.20 (0.12, 0.28) for the Q4 group, when compared with the Q1 group (the lowest LE8 score). When analyzed as a continuous variable, each 5-point increase in LE8 score was associated with a 20% lower risk of AAA. The association between LE8 score and risk of AAA remained robust after sensitivity and subgroup analyses.Conclusion: Higher LE8 score was associated with lower risk of AAA in the general population, emphasizing the importance of maintaining a healthy lifestyle to prevent AAA.","PeriodicalId":9039,"journal":{"name":"BMC Public Health","volume":"25 1","pages":"2456"},"PeriodicalIF":3.5000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257669/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12889-025-22758-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The healthy lifestyle factors have been closely associated with the risk of abdominal aortic aneurysm. The American Heart Association (AHA) recently released a checklist of health factors known as Life's Essential 8 (LE8) to optimize cardiovascular health. The aim of this study was to test the hypothesis that greater adherence to the LE8 score was associated with a decreased risk of new-onset abdominal aortic aneurysm (AAA).

Methods: This study included 279,251 UK Biobank participants without a history of AAA. LE8 score was calculated using 8 metrics according to the AHA's definition, and the study population was divided into four groups based on LE8 quartile. The Cox proportional hazard model was used to assess the association between LE8 score and risk of AAA.

Results: During a median follow-up of 12.77 years, 1042 cases of incident AAA were identified. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of AAA was 0.52 (0.43, 0.64) for the Q2 group, 0.39 (0.32, 0.49) for the Q3 group, and 0.20 (0.12, 0.28) for the Q4 group, when compared with the Q1 group (the lowest LE8 score). When analyzed as a continuous variable, each 5-point increase in LE8 score was associated with a 20% lower risk of AAA. The association between LE8 score and risk of AAA remained robust after sensitivity and subgroup analyses.

Conclusion: Higher LE8 score was associated with lower risk of AAA in the general population, emphasizing the importance of maintaining a healthy lifestyle to prevent AAA.

查看原文本刊更多论文

生命基本8分与腹主动脉瘤风险之间的关系：来自英国生物银行数据的前瞻性队列研究

背景：健康的生活方式因素与腹主动脉瘤的发病风险密切相关。美国心脏协会（AHA）最近发布了一份健康因素清单，被称为生命必需的8项（LE8），以优化心血管健康。本研究的目的是验证一个假设，即更严格地遵守LE8评分与新发腹主动脉瘤（AAA）风险降低有关。方法：本研究纳入279251名无AAA病史的UK Biobank参与者，根据AHA定义使用8个指标计算LE8评分，并根据LE8四分位数将研究人群分为四组。采用Cox比例风险模型评估LE8评分与AAA风险之间的关系。结果：在中位随访12.77年期间，鉴定出1042例AAA事件。调整潜在混杂因素后，与Q1组（LE8评分最低）相比，Q2组AAA的风险比（95%置信区间）为0.52 (0.43,0.64)，Q3组为0.39 (0.32,0.49)，Q4组为0.20（0.12,0.28）。当作为一个连续变量进行分析时，LE8评分每增加5分，AAA风险降低20%。在敏感性和亚组分析后，LE8评分与AAA风险之间的相关性仍然很强。结论：LE8评分越高，一般人群发生AAA的风险越低，强调保持健康的生活方式对预防AAA的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.